Biochemistry
@BiochemistryACS
An international forum for publishing exceptional, rigorous, high-impact research across all of biological chemistry. EIC: @AlannaSchepartz, @UCBerkeley
ID:708762999260114944
http://pubs.acs.org/biochemistry 12-03-2016 21:14:02
2,7K Tweets
7,9K Followers
1,2K Following
CO2 impacting signaling:
Pawloski et al expand on initial reports of ubiquitin carbamylation, testing susceptibility of all amines & finding candidates that likely affect polyUb-mediated pathways in cells.
pubs.acs.org/doi/10.1021/ac…
#tbt
#PTM
Univ. of Maryland
Johns Hopkins Arts & Sciences
Aldehyde dehydrogenases are of interest in understanding disease and #biocatalysis .
Soulimane, Luis Padrela and colleagues University Of Limerick examine an unusual C-terminal extension found in thermophilic ALDHs, finding impacts on kinetics, stability & specificity.
pubs.acs.org/doi/10.1021/ac…
Did you know that the world’s deadliest animal is the #mosquito ? A path towards new super-specific insecticides takes advantage of the unique biochemistry of mosquito larvae guts, as published in J. Am. Chem. Soc.. Read more: brnw.ch/21wIQxE ACS Publications #Research
New issue! 📣
Read up on enhanced antibodies, microsatellites, proteasomes, ethylene formation, chitin production, and more!
pubs.acs.org/toc/bichaw/63/8
Cover image: Auchus and colleagues University of Michigan explore how P450 11B2 catalyzes 3 consecutive oxidations.
pubs.acs.org/doi/10.1021/ac…
A three-continent collaboration explores the potential convergent evolution of glucanases, critical for grain germination in barley.
pubs.acs.org/doi/10.1021/ac…
#glycotime
#plantbiochemistry
#proteinevolution
KTH Royal Institute of Technology
Taipei Medical University
@uniofadelaide
IBM Research
University of Auckland | Waipapa Taumata Rau
ICYMI: @Sasa10447 et al unravel the catalytic mechanism of an important antioxidant enzyme from M. tuberculosis, revealing how sulfoxides are reduced.
Now an #ACSEditorsChoice paper!
pubs.acs.org/doi/10.1021/ac…
#mycobacteria
Toward plastic recycling:
@courtadegaston and colleagues characterized a PET-hydrolyzing cutinase from Fusarium solani pisi, revealing opportunities to improve enzyme activity and tune degradation products.
pubs.acs.org/doi/10.1021/ac…
#biocatalysis
#tbt
NTNU
Aalborg Universitet
The enzyme EFE can form ethylene or hydroxylate Arg (en route to guanidine), both of biotechnological interest.
Chatterjee et al use substrate analogs and mutants to dig into active site interactions, enabling future applications.
pubs.acs.org/doi/10.1021/ac…
#metalloenzymes
Cell death mechanisms:
Zhu and colleagues The Chinese University of Hong Kong - CUHK show 4-hydroxyestrone protects against ferroptotic cell death and binds to protein disulfide isomerase, providing further support that PDI is a meaningful target to prevent ferroptosis.
pubs.acs.org/doi/10.1021/ac…
#cancer
📢Call for Papers!📢
#Biochemistry is putting together a Virtual Special Issue Guest edited by Albert Bowers and Roberto Kolter to honor the late Christopher T. Walsh and the current research inspired by his work.
More information ➡ go.acs.org/8OO
Recent results are helping to understand how PI31 inhibits the 20S #proteasome , but how general are these results?
Wang, Kjellgren & DeMartino test PI31's ability to inhibit additional forms, finding surprising differences.
pubs.acs.org/doi/10.1021/ac…
UT Southwestern Medical Center
#proteostasis
A kinetic analysis of GPDH highlights the important catalytic advantages obtained by an enzyme that undergoes substrate driven induced-fit conformational changes.
From Cristobal, Hegazy and Richard UB Dept of Chemistry
pubs.acs.org/doi/10.1021/ac…
#hydridetransfer
#enzymeevolution
New cell death pathway:
Celastrol-induced paraptosis does not involve mitrochondria-ER membrane fusion, but Aoki & colleagues Tokyo University of Science (TUS) examine new molecules that appear to induce paraptosis via fusion.
Read about 'paraptosis II' in this #tbt paper:
pubs.acs.org/doi/10.1021/ac…
We are proud that our latest work in Biochemistry has been selected for the ACS Editors' Choice program. And so, it has been made freely available, which is very significant for us.
Santiago Sastre CEINBIO fmedoficial
Aryl nitriles are promising reagents for click chemistry.
Patel et al @UCL now explore mechanisms to trap nitriles via the addition of two thiols, generating stable conjugates in test molecules and antibodies.
pubs.acs.org/doi/10.1021/ja…
J. Am. Chem. Soc.
#bioconjugation
#click
New issue! 📣
Read up on telomeres, cone pigments, cryo-EM, lasso peptides, targeted aptamers and chimeric antigens, retaining glycosyltransferases, and more!
pubs.acs.org/toc/bichaw/63/7
#darpin
#glycotime
#covid
#biosynthesis
#bioinformatics
NMR & MS reveals a new immune pathway that links viperin to viral defense.
From Sala et al Murdoch University @univallecol Imperial College London Werner Siemens Imaging Center
pubs.acs.org/doi/10.1021/ac…
#covid
Journal of Proteome Research
#ACSEditorsChoice
