Antisense oligonucleotides (ASO) targeting an exon in SCN1A are being investigated as treatments for Dravet syndrome. Yuan et al. show that ASOs restore firing properties, GABAergic signalling, and sodium currents in the brains of Dravet syndrome mice. tinyurl.com/364zpm92

Stikvoort et al. report that nerve excitability in ALS is characterized by four unique patterns, each originating from changes in different membrane properties. Changes related to altered gating kinetics of slow potassium channels predict progression rate. tinyurl.com/munc7jdf

Diabetic neuropathy is often accompanied by mechanical allodynia. O’Brien et al. report that alterations in skin-derived factors contribute to allodynia, suggesting that it may be possible to develop topical treatments for diabetic neuropathy. tinyurl.com/5n82btcy

Odeh et al. examine how mutations in the SLC1A4 transporter give rise to neurodevelopmental delay and microcephaly. Using three mouse models, they show that Slc1a4 mutations lead to reduced serine import into the brain, resulting in impaired brain growth. tinyurl.com/3fnzvun9

In a study involving 400 glioma patients, Ng et al. use multivariate lesion-symptom mapping to shed light on neurocognitive systems with limited compensatory potential, and to disentangle the effects of intra- vs supra-tumoural resections on cognition. tinyurl.com/2zbtsv4j

Using cross-sectional structural MRI, Baumeister et al. identify two distinct patterns of brain atrophy in a memory clinic-based sample of older adults. These atrophy patterns may be used to predict clinical and cognitive trajectories of patients. tinyurl.com/2775sj8b

Explore our new Alzheimer's Collection - we invite our readers to enjoy some of the most stimulating and provocative papers on the neuroscience and neurology of Alzheimer’s disease.

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By wirelessly recording signals from deep-brain stimulators in patients with Parkinson's disease in an outpatient setting, Soh et al. show that the STN – known for its role in motor control – also exerts control over attentional processes. tinyurl.com/mvuwy785

FTD and ALS share overlapping genetics and pathologies. Clayton et al. summarise recent evidence suggesting that presynaptic dysfunction is an early and common event in both diseases, and could be a target for future disease-modifying therapies. tinyurl.com/mx8xpkh8

Why do female patients with AD have more pronounced tau pathology compared to males? Wang et al. provide evidence that amyloid modulates tau phosphorylation in a sex-specific manner, contributing to faster neurofibrillary tau accumulation in females. tinyurl.com/5n7jfpf8

Fernandes et al. report that mice lacking the leptin receptor show reduced brain volume and neurogenesis as well as memory impairments in association with obesity. Restoring leptin receptor expression reversed the impairments in adult animals. tinyurl.com/3sxvwcpa

In a retrospective study, Eriksson et al. show that epilepsy surgery was able to halt and even reverse a decline in neuropsychological functioning in certain children by providing seizure freedom and the opportunity to discontinue antiseizure medication. tinyurl.com/2s3wu9u6

Sarton et al. investigate the relationship between neuroinflammation, measured in vivo using TSPO PET, and neurological outcomes in patients with coma following cardiac arrest or traumatic brain injury. tinyurl.com/2s9j4xa7; tinyurl.com/ftswa9u8

Apathy is a common complication of Parkinson’s disease. Gilmour et al. show that apathy can be related to a reduced ability to use information encoded in the frontal lobes about the outcomes of an action. tinyurl.com/35hz4kej; tinyurl.com/y9r843v7

Cheng et al. show in a mouse model of ischaemic stroke that a failure of myelin regeneration contributes to neuronal loss, whereas a pro-myelination drug promotes neuronal survival and functional recovery. tinyurl.com/2kbvct7d; tinyurl.com/47yc97sd

Neurostimulation can reduce seizures in drug-resistant epilepsy, but rarely results in seizure freedom. Anderson et al. show that more frequent stimulation during periods of lower seizure risk correlates with better clinical outcomes. tinyurl.com/4zdetnnw

Sánchez-Juan et al. reveal an association between serum GFAP and post-mortem tau pathology in patients with dementia, independent of amyloid deposits. Pre-mortem serum GFAP is negatively correlated with post-mortem brain weight. tinyurl.com/2n66efrs

Hydrocephalus is the most common disease requiring neurosurgery in children. Singh et al. show an association between mutations in the chromatin remodelling gene SMARCC1 and congenital hydrocephalus with a variety of syndromic features. tinyurl.com/3rxbrb72

Corriveau-Lecavalier et al. show that dementia syndromes targeting executive functions have different signatures of brain degeneration to those affecting personality and behaviour, with implications for diagnosis and symptom management. tinyurl.com/5n8prmbx

Paß et al. present a mouse model which mimics the lifelong accumulation of mtDNA mutations in nigral DAergic neurons. The mice show normal motor function in old age, due to a compensatory increase in synaptic terminals originating from surviving neurons. tinyurl.com/tb9wy4mt