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http://DNAdigest.org 13-07-2011 21:22:41
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We developed a new method, CoronaHiT, for sequencing up to 95 SARS-CoV-2 genomes on a Oxford Nanopore MinION flowcell for our COVID-19 Genomics UK (COG-UK) Consortium work. Cheap and easy - using nextera and PCR barcoding of ARTIC Network PCR products. biorxiv.org/content/10.110… Dave Baker Andrew Page @[email protected]
It's not been an easy ride by any means, but very proud of what COVID-19 Genomics UK (COG-UK) Consortium have achieved in a short timescale: article in The Lancet Microbe today describes the distributed and diverse sequencing and analysis model we chose for genomics of SARS-CoV-2: thelancet.com/journals/lanmi…
Finally, as I settle into my new role in Australia, I am delighted to have left gnomAD leadership at Broad Institute in the very safest of hands - new co-directors Mark Daly and Heidi Rehm. Looking forward to working with them on many future data releases and much cool science!
The gnomAD team are data parasites - we are completely dependent on the generosity of principal investigators willing to share their data from independent research projects. Without the 109 (!) PIs who donated data to this project there would be no gnomAD: gnomad.broadinstitute.org/about
As well as to everyone else who made this project possible, expecially Jessica Alfoldi, Laurent Francioli, Grace Tiao, Matthew Solomonson, Nick Watts, Ben Weisburd, Kristen Laricchia, and the teams from Broad DSP and Hail.
Massive thanks and congratulations to all of the lead authors on this collection of papers - Konrad Karczewski, Eric Vallabh Minikel, Beryl Cummings, Ryan Collins, Nicky Whiffin, Qingbo Seiha Wang, Irina Armean, PhD, Aaron Kleinman, and Harrison Brand.
I'll have tweets later in the day about the science that went into this package, but here are some excellent summaries:
Broad Institute coverage: broadinstitute.org/news/internati…
Great News and Views piece by Deanna Church (she/her): nature.com/articles/d4158…
Nature editorial: nature.com/articles/d4158…
#RECOMB2020 will take place entirely virtually on June 22-25, 2020, with required registration (at the link recomb2020.org/registration ) but no registration fee. More info on schedule and refunds at our website recomb2020.org .
The COG-UK weekly reports are now getting posted up on the COVID-19 Genomics UK (COG-UK) Consortium site. The first report was back on 23rd March, 11 days after first meeting! Back then we saw a greater diversity of international lineages in UK, reflecting the multiple imports: cogconsortium.uk/wp-content/upl…