New work led by Mohammad Saadatagah Mohammadreza Naderian in JAMA Cardiology underscores that not all CHIP 🩸🧬 is the same. TET2 CHIP assoc'd w/ ⬆️ IL-6 and AF risk, esp when clones are large.

jamanetwork.com/journals/jamac…

Art Schuermans Alex Bick Pradeep Natarajan Iftikhar J. Kullo Christie Ballantyne

The results are in: Queen's Nephrology has landed in 8th place (of 1182 entries) in this year's #NephMadness competition.

🇨🇦🏆

tourneytopia.com/AJKD/NephMadne…

Off to a good start… Queen’s Nephro tied for first place after round 1 of #NephMadness 😎 Samuel Silver 🇨🇦🇮🇱 Susan Thanabalasingam

TET2 clonal hematopoiesis is enriched among individuals receiving solid organ transplantation. While this didn't predict transplant outcomes, whether it plays a role in the ultimate transplant indication requires further study aacrjournals.org/clincancerres/… AACR Alex Silver…

At least 25 researchers in our field must have had this idea cross our minds at least once. Only one of us had the crazy will to give it a real go. I think there’s a “before” and “after” this paper for those of us working on HSC heterogeneity.

nature.com/articles/s4158…

Please watch if you are doing kidney research in Canada. So informative including for the next generation of scientists!

Congratulations Dr. Paula James Paula James & BRAID team (Blood Research and Innovation Dynamic) on TEAM GRANT CIHR for 'Early genomic testing for inherited bleeding disorders in patients without a diagnosis after first line testing: an RCT' @QueensuTIME Queen's U Department of Medicine !

Completely blown away by the neon-inspired creativity of this year's #NephMadness parties 🎉🍪🎂🪩

4⃣ days left to submit 2 brackets/email address at nephmadness.com

Content here:
ajkdblog.org/category/nephm…

#FOAMed #Nephrology #NephMadness Party AJKD

So far it has been

McGill University (2021)
Queen's University (2022) and
U of T Nephrology (2023)
to be the Canadian Program with top #Nephmadness scores and bragging rights!

Who will it be this year?

APOL1 Genotyping Is Incomplete without Testing for the Protective M1 Modifier p.N264K Variant

Recently, two papers have robustly and independently validated genetically the protective effect of the #APOL1 N264K missense variant against #FSGS and #CKD
Read about some of the…

Excited to share this paper in Blood Advances led by Brett Heimlich, Pawan Bhat & Alyssa Parker with Ferrell Lab that uses mitochondrial lineage tracing techniques pioneered by Peter van Galen Caleb Lareau, Vijay Sankaran to identify transcriptional consequences of #CHIP

Join us for round 2 of the Queen's Internal Med #MedicalGrandRounds ! Caitlyn Vlasschaert & Dr. Susan Thanabalasingam will present their respective research on kidney injury and disease!

🗓️Thursday, March 28 at 7:45AM
📧Contact [email protected] for the link!

A new study from Alex Bick & Ferrell Lab labs led by incredible Brett Heimlich, Pawan Bhat & Alyssa Parker!
Comprehensive multi-omic profiling of 66968 single cells unveils that TET2 & DNMT3A mutations in Clonal Hematopoiesis drive distinct inflammatory pathways,…

Not read the tomasz baniak RaDaR paper yet? Then get on with it! #AlportWorkshop thelancet.com/journals/lance… Prof Danny Gale

Blood mutations increase risk for acute kidney injury. Learn about new collaborative research led by Queen's University's Caitlyn Vlasschaert in Nature Medicine: bit.ly/3wWH9iA #kidneyhealthinternational #healthykidneymonth #kidneyhealthforall Vanderbilt University Caitlyn Vlasschaert

Congratulations to Joanna Cunanan on her first PhD paper, coincidentally in time for #WorldKidneyDay2024 ! Mice with a Pax2 missense variant display impaired glomerular repair | American Journal of Physiology-Renal Physiology journals.physiology.org/doi/abs/10.115…

NEPHMADNESS PART 2!! AJKD NephMadness
🫘🫘
Learn to correct Na in our recent episode, written by: Dr. Caitlyn Vlasschaert (IM Resident), reviewed by: Dr. Jeff Kott (Intensivist & Nephro Fellow) & Dr. Kallirroi Laiya (Intensivist & Internist)
#NephMadness #MedEd #MedTwitter

Very encouraging data from cohort 2 of the Ph1B trial of the anti-miR-17 drug RGLS8429 in individuals with ADPKD
⭐️ ⬆️Urinary PKD1/2 protein levels after 3-mon RGLS8429 Tx
⭐️⬇️ Kidney volume in patients with the highest PKD1 increase

Press release👇
ir.regulusrx.com/2024-03-12-Reg…

We teamed up with the AJKD NephMadness team to bring you a special double-header on hyponatremia!

Written by: Dr. Caitlyn Vlasschaert (IM Resident)
Reviewed by: Dr. Jeff Kott (Intensivist & Nephro Fellow) & Dr. Kallirroi Laiya (Intensivist & Internist)

#NephMadness

Clonal hematopoiesis is shown to be associated with a greater risk of acute kidney injury and worse outcome following injury, as demonstrated using multiple patient cohorts, Mendelian randomization analysis and mechanistic studies in mouse disease models nature.com/articles/s4159…