Spatial omics of 'mini-colons' with #optogenetics for understanding how cancer progresses
nature.com/articles/s4158…
nature.com/articles/d4158…
nature natureNV
Matthias Lutolf Riggi Lab
'Surprisingly, cell death emerged as the primary response of the tissue after cancer arises.'

The accompanying editorial reviews the persistence issue quite well
thelancet.com/journals/lanin…
Danilo.Buonsenso_Surf4Children noting work of Michael Peluso, MD and Prof. Akiko Iwasaki

Emulsifiers are a key and pervasive component of ultra-processed foods. Now a 14-year study of >104,000 participants indicates an association w/ higher risk of Type 2 diabetes (Figure, annotated)
Bernard Srour INRAE_International
thelancet.com/journals/landi…

How #SARSCoV2 can disrupt brain synapses
nature.com/articles/s4156…
nature.com/articles/s4156…
Increased expression of 3 synaptic proteins, and finding a drug that restores synaptic function
Nature Microbiology

Most brain cells have lost their ability to divide. But the ones that can divide (get into cell cycle) — are more frequent in people with Alzheimer's and Parkinson's—quickly become senescent and die, and may contribute to neurodegeneration
journals.plos.org/plosbiology/ar… PLOS Biology

The gut microbiome and #LongCovid :
'Gut microbiome-based multi-label machine learning accurately predicts upcoming long-term symptoms after acute COVID19.'
cell.com/cell-host-micr…
Cell Host & Microbe by Siew Ng CUHK Medicine and colleagues

In a recent update on the FLiRT variants I wrote:
'There haven’t been any lab studies yet to determine how well that updated vaccine will fare against the FLiRT variants, but we’ll probably see some soon.'
Thinking Yunlong Richard Cao and team were on it. Yup 🙏
erictopol.substack.com/p/are-we-flirt…

We've been wondering how well the current XBB.1.5 booster shots hold up vs JN.1 and its FLiRT variant descendants like KP.3. The answer: not well.

The story of frequent persistence of #SARSCoV2 in multiple organs after mild Covid keeps getting stronger, and correlates (odds ratio >5) with symptoms of #LongCovid
🆕The Lancet Infectious Diseases
thelancet.com/journals/lanin…

Reupping for #EarthDay2024

Also protecting vs influenza A in mouse model (Figure).
Unanticipated results for an antibiotic vs upper respiratory virus infections, deserving further clinical trial assessment

Repurposed: Intranasal administration of neomycin, an antibiotic, led to protection in mouse and hamster models vs Covid, and (neosporin) raised interferon expression in humans
pnas.org/doi/10.1073/pn…
PNASNews Prof. Akiko Iwasaki Tianyang Mao Yale Department of Immunobiology

Brain activation mapping in people with low and high BMI and ability to modify eating behaviors
pnas.org/doi/10.1073/pn…
PNASNews

Good summary by Prof. Christina Pagel on FLiRT variants christinapagel.substack.com/p/covid-levels…
On avian flu (H5N1) 239 genome sequences from infected animals were released by Dept. of Agriculture last night, so we should know soon if there are any notable new mutations
aphis.usda.gov/livestock-poul….

What if you could diagnosis most cancers cheaply and quickly from a dried serum spot like what's used for screening newborns?
nature.com/articles/s4189…
NatureSustainability

Owing to concerns for aspiration and delayed gastric emptying, GLP-1 drugs are recommended to be withheld before surgery. New data suggest this may not be necessary
jamanetwork.com/journals/jama/… JAMA Anjali Dixit, MD, MPH Stanford Anesthesiology