Determinants of plasma levels of proglucagon and the metabolic impact of glucagon receptor signalling: a UK Biobank study
Congrats to Marie Winther-Sørensen and Nicolai J. Wewer Albrechtsen and team for publishing this piece in Diabetologia 👌🤩👏
link.springer.com/article/10.100…

Intra-islet glucagon signalling regulates beta-cell connectivity, first-phase insulin secretion and glucose homoeostasis

sciencedirect.com/science/articl…

“These data [] support a possible therapeutic role for glucagonergic agents to restore the insulin secretory capacity lost in #T2D ”

A long-acting #LEAP2 agonist as a new treatment for #MAFLD #fattyliver and #obesity ? Kripa Shankar and the rest of the TheRealZigmanLab say YES! #ghrelin

authors.elsevier.com/sd/article/S22…
preprint now available Molecular Metabolism

UT Southwestern Medical Center UTSW Internal Medicine UTSW O'Donnell Brain Institute UTSWdiabetes

Prevalence and predictive features of #MASLD in #T1D

Prevalence of MASLD in T1D remains unclear. Here, Coco Fuhri Snethlage et al. investigated the prevalence and severity of MASLD in T1D, and assessed clinical features of importance for predicting MASLD severity👌

academic.oup.com/ejendo/advance…

Remember that LIVER-expressed antimicrobial peptide 2 (LEAP2) also is robustly expressed in the gut🤓 Here's the expression profile💁‍♂️🤗

Intestinal Expression Profiles and Hepatic Expression of LEAP2, Ghrelin and their Common Receptor, GHSR, in Humans

pubmed.ncbi.nlm.nih.gov/38657907/

Exploratory physiological experiments are not clinical trials - Cell⁩ ⁦Cell Metabolism⁩

Some considerations to take into account when performing health-related interventions, including exercise or diet.

Thx Erik A. Richter⁩ 👍 sciencedirect.com/science/articl…

Decoding the influence of central LEAP2 on food intake and its effect on accumbal dopamine release
pubmed.ncbi.nlm.nih.gov/38641041/
'...central LEAP2 has a profound effect on dopaminergic reward signaling associated with food'

New! Online now: Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK dlvr.it/T5vcmz

New! Online now: Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation dlvr.it/T5s0Bp

A single-cell/single-nucleus transcriptomic and chromatin accessibility map of human limb skeletal muscles encompassing over 387,000 cells/nuclei from individuals aged 15 to 99 years with distinct fitness and frailty levels nature.com/articles/s4158…

Today, we report that chronic intermittent fasting impairs β-cell maturation and function in adolescent mice. Using scRNA-seq of islets we define a β-cell maturation score, which was linked to T1D in humans. 👇
biorxiv.org/content/10.110…

Patients with autoimmune liver disease have glucose disturbances that mechanistically differ from steatotic liver disease

Recently out in AJP-Gastrointestinal and Liver Physiology: pubmed.ncbi.nlm.nih.gov/38625142/

👌

Hagelqvist et al.:

'Individuals with #T1D exhibit a hypercoagulable hemostatic profile compared to healthy controls, and exercise-related hypoglycemia may increase the susceptibility to thrombosis via both procoagulant and antifibrinolytic effects'😳

pubmed.ncbi.nlm.nih.gov/38642404/

Native human GIP has been utilised in human infusion studies for decades but a comprehensive overview of the safety of such infusions has been lacking.
Here, Mads M. Helsted, Nina L. Schaltz et al. provide a systematic review in Peptides (open access): pubmed.ncbi.nlm.nih.gov/38615716/

Reduced incretin effect precedes diabetes development following duodenopancreatectomy in individuals without diabetes

Open access in Journal of Clinical Investigation: dm5migu4zj3pb.cloudfront.net/manuscripts/17…

Stimulating intestinal GIP release reduces food intake and body weight in mice
sciencedirect.com/science/articl…
'These studies establish a physiological gut-brain GIP-axis regulating food intake in mice, adding to the multi-faceted metabolic effects of GIP'

Gupta et al. in Endocrinology:
Impact of ghrelin on islet size in non-pregnant and pregnant female mice
Accepted manuscript (open access): pubmed.ncbi.nlm.nih.gov/38626085/
'...higher plasma LEAP2 is a potentially important contributor to enlarged islet size in pregnancy.'
Endocrine Society

Expression of bile acid receptors and transporters along the human intestinal tract
Just out in Endocrine Society's JCEM: pubmed.ncbi.nlm.nih.gov/38636096/
Big congrats to HenrietteNerild for driving this🤩👏

Worth a read #MASLD

The ketone body kidney connection-β-hydroxybutyrate is a regulator of glucose and acid-base homeostasis in the kidney Molecular Metabolism sciencedirect.com/science/articl…