A risk score for cisplatin-induced AKI. Next let's test prevention in high risk patients!

bmj.com/content/384/bm…

MGH Onconephrology Shruti Gupta David Leaf

Changing the race of synthetic patients from NEJM Healer caused small but significant differences in GPT-4's
management. GPT (like all AI) encoded bias that we must recognize and address. Eric Topol NEJM thelancet.com/journals/landi…

Just published: ground-breaking study of over 23,000 RCTs in Cochrane reviews. Trials hugely underpowered for true effects. Consequently, “statistically significant” estimates seriously overestimate actual treatment effects, can’t trust them. evidence.nejm.org/doi/abs/10.105…

#HMA_VEN in #AML pts in ICU
👉🏻 majority #TP53 #FLT3 #RAS
👉🏻 CR/ CRi 75%
👉🏻 30-Day mortality 19%
👉🏻 mOS 9.5m

⁦Blood Cancer Journal⁩

Venetoclax and hypomethylating agents in critically ill patients with newly diagnosed acute myeloid leukaemia onlinelibrary.wiley.com/doi/epdf/10.11…

New PHR expert medical opinion: California police deployment of attack dogs has resulted in severe injuries, disfigurement, and disability.

PHR calls on the California legislature to ban or strictly limit the use of police attack canines in the state.

phr.org/our-work/resou…

Healthcare delivery as a business:

'KFF analysis finds that 19% of [SNFs] currently meet the required number of hours for registered nurses and nurse aides, with much lower rates among for-profit facilities (10%) when compared with non-profit and government facilities (40%).'

Just published in JCO Oncology Practice after years of dedicated work by our team. Our prospective cohort study reveals the profound influence of financial toxicity on cost-cutting behaviors and diminished quality of life in patients undergoing stem cell transplant

ascopubs.org/doi/abs/10.120…

New serum FLC reference ranges for adults (including older adults) with normal renal function, courtesy of iStopMM. Hopefully these will reduce unnecessary MGUS workup and patient anxiety. #ASH23 #mmsm #nephpearls #gerionc

Happy to share one of the studies I had the privilege to work in for the past two years: Time to Cancer Treatment and Chemotherapy Relative Dose Intensity for Patients With Breast Cancer Living With HIV | Oncology | JAMA Network Open | JAMA Network jamanetwork.com/journals/jaman…

40 mg of nivolumab is enough for treating HL, plus or minus chemo. Learn about resource optimization in LMICs with Héctor Vaquera #Lymsm

We mapped how every major #immune cell type responds to every major #cytokine in vivo.

IL-1, IL-2/IL-13/TSLP, β-chain, IL-6/IL-12, IL-10, IL-17, interferon, TNF, complement, growth factor, TGF-β...

Many of these responses have never been characterized.

#ImmuneDictionary 7/

interesting study in JCO Oncology Practice by Dawn Hershman & team evaluating factors associated w tx delay for pts rx oral oncolytics. receipt of financial assistance led to tx delay (median 9-->15 days). surprisingly need for prior auth did not delay tx start. ascopubs.org/doi/10.1200/OP…

✨ #ImmuneDictionary ✨is out today in nature!

Paper nature.com/articles/s4158…
Software immune-dictionary.org

We created scRNA-seq dictionary of 17+ immune cell types responding to 86 cytokines in vivo, discovered the immune system is far more complex than previously known 1/

Some ‘green light’ palliative scripts (auto consult)

Some ‘red light’ palliative scripts (soooo what’s the Q and how can we help)

And lots of ‘yellow light’ scripts

Rituximab for EBV+ after solid organ tplant to prevent PTLD #ASH23 :
- 2168 pts (!!!), median time SOT➡️EBV+ 688d
- 1.6% of pts who received R got PTLD
- 10% of pts didn't get R got PTLD
- OR 0.15 for PTLD in pts who got post-SOT R
Huge cohort! #lymsm
ash.confex.com/ash/2023/webpr…

🗑️ #JCOOP Policy & Practice: Mis-sized packaging leads to millions of dollars in drug waste annually, from vial splitting to pharmacokinetics. Now is the time to act to reduce waste in oncology medications. ➡️ brnw.ch/21wETSx @hannahrabrams Rahul Banerjee, MD, FACP #MedOnc

Go Jennifer & Emily Liang! Super interesting & relevant concept.

We're not talking enough about the fact that the 2024 CMS physician fee schedule included caregiver training as a reimbursable service a few weeks ago

notion.so/a3886c8c84684b…

Two Doctors Without Borders cars were deliberately hit, killing one MSF staff’s family member and injuring another.

We are calling for an immediate ceasefire, which is the only way for corridors to be implemented in order to safely evacuate trapped civilians. #Gaza