Rapid initial optic nerve head capillary density loss from optical coherence tomography angiography was associated with a faster rate of visual field progression and a doubling of the risk of developing event progression. ja.ma/3UnlHv6

In this study, an LLM chatbot had comparative diagnostic accuracy and completeness in glaucoma and retina against fellowship-trained ophthalmologists in both clinical questions and clinical cases. ja.ma/3vUbRZB

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A 2-week-old newborn was referred to a pediatric ophthalmology department for divergent strabismus. The infant had a superior cleft lip, hypertelorism, and a morning glory disc anomaly in the left eye.

ja.ma/4aQH0Mt

In this case series, within 1 month at a single institution, 3 cases of acute, severe intraocular inflammation were noted following injection of faricimab. Cluster suggests such events may be more common than anticipated from faricimab trial reports. ja.ma/3vU3Fsh

Higher polygenic risk score was associated with increased risk for primary open-angle glaucoma in patients with ocular hypertension. The inclusion of a PRS improved the prediction of POAG onset. ja.ma/3U6FgYF

This cohort study investigates the association of neighborhood-level social determinants of health with lapses in diabetic retinopathy care by race and ethnicity. ja.ma/44fdv4A

In a phase II clinical trial, a group assigned to oral minocycline, a microglial inhibitor, did not have slower geographic atrophy progression over 24 months compared with a 9-month run-in phase, in age-related macular degeneration. ja.ma/3UnXKoP

After 1-year of daily irradiation using 650-nm low level red light (LLRL) compared with no LLRL, mean change in refraction was almost 1 diopter more myopic, with about one-third of a mm greater axial length in controls; no adverse effects noted in retina. ja.ma/4b5WPi4

SHR8028, a cyclosporine ophthalmic formulation, showed superiority over vehicle in improving tCFS in Chinese participants with dry eye disease at day 29. ja.ma/447jyIE

Most viewed in the last 7 days from @JAMAophth:

A 2-week-old newborn was referred to a pediatric ophthalmology department for divergent strabismus. The infant had a superior cleft lip, hypertelorism, and a morning glory disc anomaly in the left eye.

ja.ma/4aRVLPo

Large epidemiologic study showed increased uveitis risk at 3 and 12 months after COVID-19 vaccination in those with histories of uveitis of 8.6% and 16.8%. Risk varied with vaccine types, supporting monitoring those at potentially increased risk. ja.ma/4b6iTt0

No home-monitoring vision test evaluated provided satisfactory diagnostic accuracy to identify active nAMD diagnosed in hospital eye service follow-up clinics. ja.ma/3Ue7Yqu

Autonomous AI demonstrated high accuracy in detecting both more-than-mild retinopathy of prematurity (ROP) and type 1 ROP in infants from the US & India. ja.ma/3U2X07c

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A 28-year-old woman presented with a subconjunctival mass in the inner canthus of the left eye that had been growing for 2 years.

ja.ma/3U5lkFn

#ArtificialIntelligence chatbot demonstrated fair performance on questions pertaining to ophthalmic cases that required multimodal imaging interpretation. ja.ma/3U469w7

Scleral pathologies in highly myopic eyes through polarization sensitive-OCT suggested unique fiber patterns, which may be related to pathogenesis of pathologic myopia and dome-shaped macula. ja.ma/3U5n2Xb

The correlations between spinocerebellar ataxia type 7 disease severity and ophthalmic manifestations found in this study emphasize the potential of visual assessments as biomarkers for disease progression and therapeutic evaluation. ja.ma/3UnKoJ2

One of seven African-Americans aged 40 years or older had uncorrected refractive error, supporting the strategy of providing universal coverage for eyeglasses to reduce burden of vision loss by over two thirds. ja.ma/4aBtpc7

Case report: an 8-year-old girl who received oral sirolimus as an adjuvant therapy for pulse dye laser of her port-wine stain and as an off-label treatment of exudative retinal detachment secondary to diffuse choroidal hemangioma. ja.ma/4d5J1Gb

Vision impairment was associated with symptoms of depression, anxiety, and social isolation. These findings provide evidence to support prioritizing research aimed at enhancing the health and inclusion of people with disabilities. ja.ma/4cZWIGN