Lior Pachter Repeat with me: 'least square fits work on the assumption you chose the correct function to fit, and will spit out a result even when you didn't'.
x.com/j_bertolotti/s…

Reminds me of a joke where a married couple are in an airplane that is about to crash land on a deserted island. She says to him, “honey, did you mail our tax returns?” He says “oh dear, I was going to do it when we got home”.

She exclaims “Thank god! They’ll find us!”

What's preventing you from coding like this?

The 'assholes' part is a red herring. The issue is that bean counters began running an engineering org.

prospect.org/infrastructure…

Keen to year your thoughts Spear of Lugh 🔱 :)

Alexandros Marinos 🏴‍☠️ Free will is the dual of observation.

Will is how ideas impact the world and observations is how world impact ideas.

Quantum physics is puzzling because of the 'observer problem'. My thesis is that this problem is the flip side of the 'free will' problem.

Hey #OCaml pple, what’s the current status of compiling to warm/wasi targets?

The best etymology I've read recently has to be that Swiss mercenaries exclaiming 'by God!' in the 15th century gave Spanish its word for 'moustache', bigote.

The sad truth, and why I increasingly distrust the medical system, is:

Many things can be changed by diet and other lifestyle changes, but you can't sell people a pill for that

It shouldnt be the case but doctors are under huge economic pressure to fall in line w/ pharma…

I'm actually starting to suspect that the best manufacturers have more to teach software folk than vice versa.

This is not a strong opinion, and I want to retain the ability to revise it.

But manufacturing is harder, older, and lower margin.

Social atomisation.

Your Sunday read on distributed systems just popped on the first page of HN!

Meanwhile, I see numerous posts and overhear many conversations in which people question the significance of the humanities…

There are movies you can't unsee and this is one of them. I had no idea...

Rust is for Lacanian masochists (and I'm learning it anyway).

This is why I can’t be assed to worry about Devin. There is no substitute for understanding the thing you’re building.

Devin devs are just creating work for the rest of us.

The Trautonium. Invented early 1930s. Just listen to this thing.

Letters to the editor are the OG tweets, and the English have mastered it.

My man answering the big questions