This is where the field may head eventually...

Yes, that is one of the 4 studies.

There are now 4 papers on the topic, where the evidence suggests, but does not prove, aspirin may reduce risk of future CVD events in patients with elevated Lp(a). However, they need validation in studies where aspirin was randomized at entry in modern cohorts. ASPREE did not…

Its included, stay tuned on this, we have an editorial coming soon to address it. The LDL-C is at best an estimate, particularly in people with elevated Lp(a), hihg TGs or very low true LDL-C. ApoB does not solve this issues as it lumps all apoB together, irrespective of what is…

Ok folks, as usual, what an amazing and engaging audience! I truly love this type of interaction. Thank you and good health to all!. Signing off until next time.

yes

we are jealous...😀

Someone who has CVD, or lots of coronary calcium, or persistently high LDL-C. There are some other individualized cases also.

I dont think we have enough data on chimps in wild, but most don't live to a ripe old age. Note also they are not sedentary, quite the opposite, and have no other risk factors. Their LDL-C is also ~100.

That is a good assumption. Companies have to catch up very fast to the leaders, otherwise their product is hard make viable commercially. twitter.com/dvweisberg/sta…

MESA- there is no new idea under the sun that has not been though of already by someone else..

Yes, this is a topic of high interest for me, unfortunately I cannot obtain blood samples from those that have them to do addtional studies...

Wild chimps die of violence and parasitic infections. Captive chimps can live 50-60 years. Main cause of death in captive chimp appears to be cardiomyopathy, not atherosclerosis.

May need both at these levels.

Need to see other values

I don't know if the values were analyzed as being statistically different in primary vs secondary prevention. The study is also observational with many potential confounders. I would not read into randomized trials, but general topic is worth some consideration.

I dont know anything about gugul, need to lok up. Red rice yeast has essentially a statin it, plus a million other ingredients. Why not just take the active one approved by FDA?.

Very low carb intake may affect Lp(a). Interestingly, the highest Lp(a) levels known are in chimps who eat massive amounts of fruit daily, particularly figs. Not sure if this is related. The double edged sword of low carb is increases in LDL-C, sometimes very high, so no 'free…

Ok, will need to read and then reply, but cant do it right this minute.

You dug away back on this, thanks. I need to do more of these types of tweets, they are fun and also good teaching tools.