I am happy to share that I will be starting an assistant professor position at the Van Andel Research Institute Van Andel Institute (VAI) in the Department of Neurodegenerative Science. My lab is opening in July, and I am currently hiring: vai.wd1.myworkdayjobs.com/en-US/VAICaree… and vai.wd1.myworkdayjobs.com/en-US/VAICaree…

Thanks to the Primordium and plasmidsaurus team (and spouses) for merging our websites on Mother's day. Everyone can now access all services and dropboxes! This new website will enable us to rapidly push new features. Stay tuned!

Check it out: plasmidsaurus.com

20 jobs?! Use this tool from Ernst Schmid to submit jobs faster.

Riding the #AlphaFold3 wave with a new analysis tool. It’s super new/unpolished, but would love to get community feedback! Extract and filter residue level interaction data from your AF3 server prediction zip files! Try it here: predictomes.org/tools/af3/

I feel like playing with DALLE... The models look great but when you look closer some things are new and impressive, but some things seem hallucinated. Care and experimental validation thus as always required!
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0/10 jobs left.

Very exciting! The future is bright but the scientific community needs access to the model to run large scale efforts.

Online Now: The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex dlvr.it/T6VL01

Congratulations Danesh Moazed of Harvard Medical School, newly inducted #NASmember ! #NAS161 #genetics #cellbiology

Congratulations J. Wade Harper of Harvard Medical School, newly inducted #NASmember ! #NAS161 #biochemistry #cellbiology #microbiology

Excited to share (with my 8 followers) graduate student Ernst Schmid’s “SPOC” classifier, which can pick a good AlphaFold-Multimer prediction out of a crowd, and predictomes.org, a database of PPIs in the genome maintenance space.

biorxiv.org/content/10.110…

My work in Johannes Walter’s lab on developing a classifier to score AF-multimer predictions (alongside a large scale screening effort) is out as a preprint now! biorxiv.org/content/10.110… @Johanne23743184

another #giantvirus with #histones y'all! Medusavirus has them all - even a putative linker histone! Check out Medusavirus nucleosome structures (and more) in our new preprint by the amazing Chelsea Toner and Nicole Hoitsma, PhD biorxiv.org/cgi/content/sh…

AlphaFold reshapes structural biology. Ernst Schmid and Johannes Walter from Harvard Med BCMP have developed a proteome-scale protein-protein interactions platform (predictomes.org) and a classifier to accelerate biological discovery. The future. Now! shorturl.at/cikqC

Congratulations to twitter less Bonnie Su on her first paper from the lab! Bonnie shows that NELF can bind Pol II in two distinct confrontations that support either pausing or elongation. She did this using actively transcribing complexes. Read it here: authors.elsevier.com/sd/article/S10…

Exciting visual biochemistry from Seychelle Vos to understand promoter-proximal pausing and its regulation by NELF.

Has anyone worked with visualization of PDBs/EM maps and the new Apple Vision Pro?

Come join us at Harvard Cryo-EM Center for Structural Biology to do cutting-edge cryo-EM! We have a fantastic setup, amazing colleagues and a great research environment.