Marieke Oudelaar
@MariekeOudelaar
Lise Meitner Research Group Leader @mpi_nat. Genome Organisation and Regulation. She/her.
ID:1057218495530913792
30-10-2018 10:31:46
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1,3K Followers
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Pinpointing causal variants that disrupt development. So proud of the amazing team on this epic enhancer genotype-to-phenotype study. Well Done, Fabian Lim, Joe Solvason, Genevieve Ryan, Sophia Le, Granton Jindal, Paige Steffen and Simran Jandu!!! doi.org/10.1038/s41586…
Ready to give your lab a green makeover?🌿Explore our insights on making research more sustainable in this World view by Kathryn Wattam, Matt Todd and Anja Groth 🇺🇦 in Nature Cell Biology Let's take steps towards a greener scientific future!💚🔬 #SustainableScience rdcu.be/dv82V
Check out our latest review in Trends in Genetics where we compare timescales of transcription regulatory steps (input) and transcriptional burst kinetics (output) to better understand the mechanisms of transcription regulation. doi.org/10.1016/j.tig.…
2024 starting off on the right foot: Our preprint on the repurposing of a small molecule inhibitor to induce homogeneous and SASPless replicators-like senescence to human cells is now out in Aging Cell.
onlinelibrary.wiley.com/doi/10.1111/ac…
Interested in transcription & chr. folding?
A reminder of our work w/ O Espeli (or jump to nature.com/articles/s4159…)
Charlie Reid (Cockram) used a trick to activate a single transcription track along a transcriptionally inactive E. coli genome.
The result? a TID! (Transcription Induced Domain)
2nd episode...
How do the embryos remain alive in the dormant state? Our Vera van der Weijden showed that they completely switch the metabolic profile and use lipid reserves. Now online as post-review publication 10/ nature.com/articles/s4155…
A new chapter in our quest to understand long-term transcriptional memory! biorxiv.org/content/10.110…
A unique chromatin signature remembers past gene activation for multiple cell doublings without the signal. Fascinating work by Pawel Mikulski and our team!
Please apply if you are interested to join our team MPI for Multidisciplinary Sciences in Göttingen (Germany) as a PhD student and to study the 3D organisation and regulation of the genome!
Happy to share our new preprint about the chromatin binding kinetics of cohesin and CTCF during zebrafish embryogenesis by Jonas Coßmann (SMT, Gebhardt Lab) and Pavel Kos (simulations, Luca Giorgetti). Thanks also to Vassiliki Varamogianni-Mamatsi (@AkisPapantonis).
Really excited to join the @embo_yip network — many thanks to our team for their amazing work and MPI for Multidisciplinary Sciences for support!
Just out NatureStructMolBiol! Our work on mapping 3D enhancer networks in early embryonic lineages and introducing the 3D-HiChAT model for predicting transcriptional behaviors and functional hubs of gene coregulation. rdcu.be/dsN4W
Are you interested in mapping six or more chromatin profiles in single cells? With a method that is unrelated to any of the current strategies? Our work on developing MAbID is out. Amazing Job by Silke Lochs and Robin H. van der Weide ! nature.com/articles/s4159…
Happy to share the first pre-print of our lab where we find that DNA repair in constitutive heterochromatin depends on specific histone acetylation activities. Thank you especially to Apfrida Kendek, Arianna Sandron and Jan Paul Lambooij for their hard work!
Our paper on patient-specific MYC enhancers in malignant rhabdoid tumors was just published in Nature Communications Please the link here: nature.com/articles/s4146…
Excited to see our fundamental research on 3D genome folding help to understand this highly aggresive and deadly disease.