Enhancer-promoter interactions are reconfigured through the formation of long-range multiway hubs as mouse ES cells exit pluripotency dlvr.it/T5sPJq

A programmable targeted protein-degradation platform for versatile applications in mammalian cells and mice dlvr.it/T5s8Qr

Imprinted X chromosome inactivation at the gamete-to-embryo transition dlvr.it/T5rrNw

Happy #EarthDay2024 ! Have you considered how your research impacts the Earth? Check out this collection in Molecular Cell for some examples of labs trying to help reduce the negative impact and trying to have a positive impact - cell.com/molecular-cell…

Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH dlvr.it/T5rdk6

A kinetic dichotomy between mitochondrial and nuclear gene expression processes dlvr.it/T5rP5J

A unique chaperoning mechanism in class A JDPs recognizes and stabilizes mutant p53 dlvr.it/T5pZJ9

Nucleolar stress caused by arginine-rich peptides triggers a ribosomopathy and accelerates aging in mice dlvr.it/T5mjw6

Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape dlvr.it/T5lQZh

Mitotic chromosomes are self-entangled and disentangle through a topoisomerase-II-dependent two-stage exit from mitosis dlvr.it/T5l4lg

Molecular determinants and signaling effects of PKA RIα phase separation dlvr.it/T5krBr

The splicing regulators RBM5 and RBM10 are subunits of the U2 snRNP engaged with intron branch sites on chromatin dlvr.it/T5kXZS

Sequential requirements for distinct Polθ domains during theta-mediated end joining dlvr.it/T5kL0F

Shining light on DHX9: UV-induced stress granules illuminate protective mechanisms for daughter cell resilience dlvr.it/T5k53n

Free ribosomal proteins as culprits for nucleolar stress dlvr.it/T5hrF2

Entangling and disentangling mitotic chromosomes dlvr.it/T5hTgv

Meet the authors: Guy Zoltsman and Rina Rosenzweig dlvr.it/T5hDrf

In a new Molecular Cell publication, researchers from Dept. of Molecular Biology, MGH and colleagues found new insights into the silencing of X-chromosome genes passed on from fathers to daughters.

Read more: massgeneral.org/news/press-rel… Jeannie Lee

Thrilled to share our work (& my first, co-first author paper! w/ Nathanael Caveney & C. Pollman) from the Garcia & Piehler groups, out today in Molecular Cell: We
propose a canonical hexameric signaling mechanism for the common beta cytokine family: cell.com/molecular-cell…