Original Article: Alectinib in Resected ALK-Positive Non–Small-Cell Lung Cancer (ALINA) nej.md/3VUzf3M

Editorial: Adjuvant Alectinib in ALK-Rearranged NSCLC — Here and Now nej.md/43WM3bU

#Oncology

R. Alta Charo discusses the potential implications of the Alabama Supreme Court’s decision in LePage v. Center for Reproductive Medicine. Listen to the full interview: nej.md/3VOWa0l

In the latest Case Records of the MGH, an 82-year-old woman was admitted because of difficulty walking, falls, and cognitive decline. Light touch of the right hand, right knee, and both feet caused pain. A diagnosis was made. Read the full case: nej.md/4aLNcoK

This Graphic Perspective by Dr. Felippe Marcondes, MD MPH & illustrated by Emily Ling follows a “Dreamer” as he pursues his dream of becoming a physician in the United States — and faces the limits of his ability to help his undocumented immigrant family. Read now: nej.md/4ah4slU

Denise Coley, who is 72 years old and was diagnosed with Parkinson's disease in 2018, explains why there needs to be more awareness about the disease. Listen to the latest episode of Intention to Treat: nej.md/itt-ep28

“Data-driven approaches have the potential to improve efficiency in the identification of the most important drivers of [heterogeneity of treatment effect] from RCTs.” Full article by Rishi J Desai et al.: eviden.cc/4cupGhU

Muthu Vaduganathan

Perspective: Corporate Medicine 2.0 — Special Purpose Acquisition Companies in the United States nej.md/3VUyTKu

#HealthPolicy

I was mispronouncing “dysgeusia” this whole time! Another great one by The Voice Stephen Morrissey Nirmatrelvir for Outpatients with Covid-19 | NEJM youtu.be/KXpsRcr3RaY?si… via YouTube

Gain a comprehensive understanding of how to talk with patients about their weight, how to assess obesity in patients, and how to incorporate healthy lifestyle changes. Sign up for this free webinar: nej.md/4cUkaVN

What began as a ground-up effort to improve clinical care through virtual reality and other immersive technology developed into a multifaceted, systemwide effort that can serve as a guide to others on improving patient care delivery: nej.md/491xCnx

Cash transfers to individuals that the U.S. government made during the Covid pandemic demonstrated how such a policy tool could help address the political–economic determinants of health. Read the Medicine and Society article by Eric Reinhart, M.D.: nej.md/3Uc70MA

Listen to the full episode: nej.md/3vXowe5

Read the full episode transcript: nej.md/3VVS9r2

The latest episode of Not Otherwise Specified considers what happens when the rigors of training and the pursuit of excellence in medicine collide with the mental health needs of trainees.

100 Years of Case Records of the MGH: In this case from October 26, 2017, a pediatric surgeon from MGH was contacted by a nonprofit organization to evaluate the possibility of surgical separation of conjoined twin girls. Read the full case: nej.md/2yTFpqn

A 70-year-old woman sought evaluation for a sensation of something moving in her nose. The sensation began during a trip to South America. What is the differential diagnosis? Read the Morning Report by Marlene M. Speth, MD, MA, et al.: eviden.cc/3IMTx7l

This Graphic Perspective by Dr. Felippe Marcondes, MD MPH & illustrated by Emily Ling follows a “Dreamer” as he pursues his dream of becoming a physician in the United States — and faces the limits of his ability to help his undocumented immigrant family. Read now: nej.md/4ah4slU

WHIM-like syndrome (warts, hypogammaglobulinemia, infections, and myelokathexis) developed in a patient with gain of CXCR4 function. Plerixafor, a CXCR4 antagonist, led to symptom reduction. Read the full correspondence: nej.md/3PWlfT3

Poor nutrition is a major risk factor for disease. In this first review in a new series on nutrition, the authors provide an overview of nutritional guidance, with a focus on energy and macronutrients. Read the full review: nej.md/43V6ypp