The hype and hope of new #foodallergy treatments
A paradigm shift is underway with new therapies emerging, including the recent FDA approval of #omalizumab - but it may not be a panacea for all.
News & Views from Prof Kirsten Perrett Murdoch Children's Research Institute (MCRI) University of Melbourne
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Nicotine e-cigarettes: considerations for healthcare providers.

Comment from Benjamin Toll, Tracy T. Smith MUSC Hollings Cancer Center and Brian A. King FDA Tobacco

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A framework for implementing patient-reported outcomes in clinical care: the PROTEUS-practice guide.

Correspondence from Norah Crossnohere The Ohio State University College of Medicine and colleagues.

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The search for authentic microbiome–disease relationships.
A new study challenges the validity of previously reported microbial markers and serves as a wake-up call for the #microbiome research field. News and Views from Ruixin Zhu & colleagues
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An antibody screen of two distinct Multiple Sclerosis cohorts reveals an autoantibody signature that is detectable years before symptom onset and linked to a common microbial motif Gavin Sowa, Colin Zamecnik, PhD, and Ahmed Abdelhak nature.com/articles/s4159…

In a series of clinically relevant tasks in #ComputationalPathology , AI-driven models display performance #disparities across ethnic groups, which self-supervision on large training datasets and existing debiasing techniques can only partially mitigate. nature.com/articles/s4159…

⭐Research highlight: A randomized controlled trial involving a telemedicine-based approach for the management of patients with acute coronary syndrome had several clinical benefits relative to standard of care. JACC Journals
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Controlling for confounders calls into question the robustness of some associations of microbiota with colorectal cancer stages. RaesLab @VIB Sam Van Campenhout #QMP #CRC #MicrobiomeCRCConfounders #QMP MicrobiomeColorectalCancer #GutColorectalcancerQMP nature.com/articles/s4159…

Implementation of organized low-dose CT screening in over 4,000 individuals with high risk for lung cancer as part of the Ontario lung cancer screening pilot program reported high cancer detection rates, early detection of cancer and low serious harms
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#AI enabled ‘wellness’ apps exist in a regulatory grey area and may pose risks if used to manage #mentalhealth issues. Julian De Freitas & I. Glenn Cohen discuss the potential risks and the implications for app developers and regulators.
Petrie-Flom Center
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Advances in bioengineering and organic chemistry have enabled targeting of the previously ‘undruggable’ #KRAS ; our latest review from Eileen M O’Reilly & colleagues discusses the successes, challenges & future of KRAS therapeutics in #cancer
Memorial Sloan Kettering Cancer Center
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A 2023 survey of 23,000 adults in 23 countries reports that the pandemic experience had reduced the participants' willingness to get COVID-19 and routine vaccination, and the trust in recommendations from public health authorities. nature.com/articles/s4159…

In a randomized clinical trial, alerts based on detection of abnormalities in #Electrocardiograms using a #DeepLearning algorithm reduced all-cause mortality at 90 days in patients admitted to hospital emergency or internal medicine departments. nature.com/articles/s4159…

Climate change and health: understanding mechanisms will inform mitigation and prevention strategies.

Comment from Robbie M. Parks and colleagues Columbia University

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Strategies for controlling pneumococcal disease and outbreaks during humanitarian emergencies.

Correspondence from Brenda Kwambana-Adams and colleagues.

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A self-amplifying #mRNAvaccine shows promise in this new modality by eliciting neutralizing antibodies against the SARS-CoV-2 Omicron (BA.1) variant in a phase 2/3 trial.
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Exploratory analysis of the 1-year clinical trial PASADENA in individuals with early-stage #ParkinsonsDisease suggests that prasinezumab might reduce motor signs progression to a greater extent in those with more rapidly progressing disease. #PD Azad Bonni
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In 6 patients with multi-drug resistant #RheumatoidArthritis , the CD19-CD3-targeting bispecific T cell engager #BiTE blinatumomab reduced disease activity and led to reductions in autoantibodies #autoimmunity Ricardo Grieshaber-Bouyer FAU Erlangen-Nbg nature.com/articles/s4159…

Reproductive rights in the United States: acquiescence is not a strategy.

Comment from Dr. Laura Esserman & Douglas Yee MD, as part of our ongoing series on Women's Health

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The QR4 #Algorithm for prediction of 10-year #CardiovascularDisease risk, tested and externally validated in large datasets, improves upon the #QRISK3 algorithm that is in current use by incorporating new risk factors. nature.com/articles/s4159…