Pooja S. Jagadish, MD
@PoojaJagadishMD
To be a good cardiologist, one must be a great internist.
Cardiologist & Clinical Educator
🫀@UAZHeart | IM @UTHSC | MD @ETSU
≠ medical advice | ≠ employer's
ID:1508537645017747474
https://www.doximity.com/cv/poojasjagadish-md 28-03-2022 20:13:41
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Use BP during Tilt Testing to Differentiate Orthostatic Hypotension (OH) from POTS!
In POTS, BP stays normal or ⬆️slightly.
In both types of OH (Immediate & Delayed), see ⬇️SBP by 20 mmHg ± ⬇️DBP by 10 mmHg immediately or in 3-5 min, respectively.
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A brief increase in HR w/in the first 20ish sec of standing is a normal, healthy response in adults >20 years.
In POTS, the HR increase starts at 30-60 sec and often continues to increase with standing. There MUST be orthostatic sxs to dx POTS.
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In POTS, the normal compensatory mechanisms for ⬇️ 🫀 & 🧠 blood flow (i.e. ⬆️HR, ⬆️peripheral vascular constriction, ⬆️inotropy) are affected, leading to ⬆️HR of at least 30 bpm (for age > 20) within 10 min of standing, NO ⬇️BP, and (+)orthostatic sxs.
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What is POTS (Postrual Orthstatic Tachycardia Syndrome)?
It is a disorder on the spectrum of autonomic dysfunction, characterized by orthostatic intolerance--worst when upright.
Ddx: orthostatic hypotension, reflex syncope, vasovaval syncope, etc.
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A Head-Up Tilt Test for syncope is POSITIVE if the patient has complete LOC +/- sxs of dizziness/lightheadedness.
Ddx: Vasovagal, Orthostatic Hypotension, Pseudosyncope.
Sometimes done with EEG to differentiate epilepsy or psych cause.
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Tilt Test Phases:
1) Supine - Monitor horizontal for 5-10 min.
2) Passive - Head-up at 60-70 degrees for ≥20 min on continuous EKG w/ vitals every 3-5 min.
3) OPTIONAL Drug Provocation - Monitor head-up for 15-20 min after SL NTG 400 mcg.
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Tilt Testing Contraindications:
AVOID Isoproterenol Tilt Testing in ischemic heart disease (Class III).
AVOID tilt testing in pregnancy (hypotension may harm fetus) or those with myocardial/cerebral ischemia that would be exacerbated by hypotension.
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Two Class I indications for Tilt Testing:
(1) Unexplained single-event syncope in a high-risk setting or recurrent syncope w/o known heart disease after cardiac etiologies are ruled out.
(2) To evaluate susceptibility to reflex syncope.
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Tilt Testing:
Can have poor reproducibility with a false negative rate >25%, dep on pt selection.
Isoproterenol & NTG ⬆️ sensitivity and ⬇️ specificity of a Tilt Test.
Vasovagal syncope CANNOT be ruled out by a negative Tilt Test but still warrants eval.
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POTS:
🫀Abnormal increase in HR to > 120 bpm within the first 10 min of standing.
🫀Syncope is driven not by this abnormal increase in HR but rather by an overlapping condition.
🫀Encourage hydration +/- electrolytes, compression socks, standing slowly.
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Orthostasis:
💩Splanchnic circ can store ~25% of blood vol.
🫀When 500-800 ccs of blood shifts to the legs/gut, there is ⬇️Venous Return and ⬇️Cardiac Output. Syncope occurs from inadequate compensation.
🫀Common in DM, Parkinson's, chemo, dehydration.
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Neurally Mediated Syncope:
😵Response to Noxious Stimuli, Baroreceptor Activation, Vagal Reflex
🫀Leads to ⬇️HR +/- ⬇️BP
🧠Usually quick reorientation. If prolonged recovery, consider head injury!
🍔Post-Exercise/Postprandial: vascular bed vasodilation
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