'A fundamental mistake in receptor theory has led to an enduring misunderstanding of how to estimate the affinity and efficacy of an agonist.'
arxiv.org/abs/2402.14617

Matthew Freeman and Fran Ashcroft discuss 'The Mould in Dr Florey's Coat' by Eric Lax in this #podcast

podcasts.ox.ac.uk/good-science-r…

I am sad to report that Bill Catterall has died. He was an enormous presence University of Washington.

A mechanism of lysosomal calcium entry | Science Advances science.org/doi/full/10.11…

The key here was to include native acyl chain length PIP2 (not PIP2-diC8).

Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis | Nature nature.com/articles/s4158…

We found the protein that imports Ca2+ into lysosomes! Just as we breathe air in and out of our lungs, a lysosome sucks in and releases Ca2+ : a trait that's at the ♥️ of how lysosomes act. Lysosomes are multifunctional – each function involves fusion with a diff organelle; a🧵

Our latest twin papers in Nature Biotechnology on reporters for organellar Na+ and organellar K+. Ion channel folks, these are for you. #ionchannels nature.com/articles/s4158…
nature.com/articles/s4158…

Eukaryotic Kv channel Shaker inactivates through selectivity filter dilation rather than collapse | Science Advances

science.org/doi/10.1126/sc…

New #LMBResearch led by Chris Russo’s group, has developed a new #cryoEM microscope running at 100 keV, capable of solving atomic structures at a fraction of the cost of existing models.

Read more: www2.mrc-lmb.cam.ac.uk/low-energy-cry…

Our latest - a long time in the making but finally out:
Extracellular modulation of TREK-2 activity with nanobodies provides insights into the mechanism of K2P channel regulation biorxiv.org/content/10.110…
Thanks in particular to: Karin, Alex.Cloake Janina Sörmann Agnese

Approaching the End of the World #Fisterra

What’s happening? Not a lot… #Galicia

Wondering what the Whipple lab has been up to? Check out our first manuscript!

Allelic chromatin structure primes imprinted expression of Kcnk9 during neurogenesis biorxiv.org/content/10.110…

Thanks Sophion Bioscience A/S for arranging such a great line up of speakers for this meeting.

Thinking of simulating anion protein interactions? David Seiferth's work is now out in PCCP:

Limitations of Non-Polarizable Force Fields in Describing Anion Binding Poses in Non-Polar Synthetic Hosts -pubs.rsc.org/en/content/art…

Congrats David! with Stephen J. Tucker as well.

We are preparing for another ⭐️ EpIC Tuesday ⭐️! A week from today Tim 🇺🇦 will share their work on evolution of ion channels. Find out more and register 👇 sgp-epic-seminars.com Society of General Physiologists Osama Harraz

Born #Today in 1910, Dorothy Hodgkin was the chemist who advanced the technique of X-ray crystallography to determine the structure of biomolecules which became an essential tool in structural biology. She was awarded the Nobel Prize for Chemistry in 1964 buff.ly/3bl7Csw

What an EpIC group of people - learn more about ion channels
sgp-epic-seminars.com #ionchannels Society of General Physiologists