Scientists showed that circ_0001671 exerts an oncogenic effect in #ProstateCancer through the regulation of bloom syndrome protein by sponging 🌕 miR-27b-3p.

🔗 go.nature.com/4bVoPp8

Anoikis plays a crucial role in the onset of tumor metastasis.

Researchers found that targeting 🎯 TUBB3 suppresses anoikis resistance and bone 🦴 metastasis in #ProstateCancer .

More here: bit.ly/3V5mZLs

One of the most important things about prostate pathology is recognizing benign mimics of adenocarcinoma. This is just basal layer hyperplasia with a pseudocribriform pattern.

#PathTwitter #GUPath

Dr. Kirsty Hodgson from the Jennifer Munkley led this study showing that inhibiting sialylation can suppress the spread of prostate tumors to bone. 🦴 @NUBiosciences

eBioMedicine – The Lancet Discovery Science | bit.ly/4dX6HNA

Ready for some mining? 🕳️

Nantong University researchers' comprehensive data mining revealed RTK/RAS signaling pathway as a promoter of #ProstateCancer lineage plasticity through transcription factors and copy number 🔢 variation.

go.nature.com/4aEi4XC

A key 🗝️ pathway underlying neuroendocrine gene 🧬 upregulation by #androgen deprivation therapy (ADT) has been revealed!

Scientists showed that the EZH2-REST axis is essential for ADT-induced NE differentiation.

👉 go.nature.com/4dUOujE

.UoM Science and Engineering scientists including Dr. Hannah Wanstall have shown that 154 MeV electrons can be used to effectively kill ☠️ lung and #prostate cancer cells, suggesting that very high energy electrons would be a viable radiotherapy modality.

go.nature.com/44N2ojR

🛋️ Sit back and enjoy a review on the anti-prostate cancer effects of six #flavonoids along with a summary of their mechanisms of action and predicted druggability.

🔗 bit.ly/3yg0xYn

A research team from TU Dresden showed that the glutamine metabolism key 🗝️ protein GLS1 is a potential target in docetaxel-resistant #mCRPC cells with a #mesenchymal phenotype and a biomarker of CRPC aggressiveness.

👉 go.nature.com/3V3RkeU

Researchers from Università di Torino investigated 🔎 the role of the Wnt signaling modulator Dickkopf-1 in the growth and metastatic progression of mCRPC.

DKK1 deletion 🚫 not only reduced prostate tumor growth but also inhibited the formation of lung metastases.

go.nature.com/4bnqOCK

Looking for a one-stop solution to stay on top of all #prostate cell research?

Our free, bi-weekly newsletter, Prostate Cell News could be your answer. It delivers the latest prostate cell research right to your inbox. 🖱️ Subscribe now!

bit.ly/4cjmXaI

Experiments performed in this study show that energy and lipid metabolism in CDK12-deficient castration-resistant #prostate cancer ( #CRPC ) work together to drive CRPC progression.

📚 Learn more: bit.ly/3yvxL64

Researchers demonstrate the role of CYB561 in facilitating transdifferentiation and maintenance of neuroendocrine phenotype in castration-resistant prostate cancer through its involvement in neuropeptide biosynthesis and iron metabolism pathways.

📖 bit.ly/3wIPaaX

⚗️ This Biological Research study reveals a novel role of LLGL2 silencing in #autophagy .

Defective expression of LLGL2 leads to attenuation of epithelial-mesenchymal transition due to the upregulation of autophagy flux in #ProstateCancer .

🔗 bit.ly/3UIKbiu

Discover the role of #sphingolipid metabolism in #prostate cancer diagnosis and treatment in this new Aging-US article.

📌 bit.ly/3UwfGwl

Researchers showed that abnormally high expression of UBE2N acts as a cancer promoter to strengthen #glycolysis and viability of #Prostate Cancer cells.

The mechanism of UBE2N is its promotion of the ubiquitination of Axin1.

bit.ly/3UD3eL4

Researchers show that the aberrant activation of transforming growth factor β/ROCK1 increased the #stemness of benign prostatic hyperplasia (BPH) tissue by recruiting #MSCs , indicating the important role of embryonic reawakening in BPH.

📌 bit.ly/4baSYRk

At the Aga Khan University (Aga Khan University), researchers found that the presence of Epstein-Barr virus in #ProstateCancer tissues results in an increased expression of certain oncogenes, oncomiRs, and vimentin & a decrease in CD3 lymphocytic infiltration.

🔗 go.nature.com/3Wqx48j

Take a ride 🚗 from biology to the clinic, exploring liver metastasis in #ProstateCancer , with this Nature Reviews Urology review.

🔗 go.nature.com/3Wsi8Xk

Methods of screening men for #ProstateCancer will be trialed in an attempt to save thousands of lives in the UK.

The £42m Transform project has the potential to reduce deaths from the disease by 40% a year!

👏 A pivotal moment indeed!

bit.ly/3wkbHuA