Curious how oligonucleotides are made on scale and what the future holds? Check out our review with lovelockresearchgroup appearing today in Science Magazine : science.org/doi/10.1126/sc…

We have optimized a human in-vitro translation system (HITS) for use in #ribosome research

Our HITS:
🧪requires a minimal number of components
💵is cheap & easy to prepare
💡enables cap-dependent translation
📈is highly active

online now: bit.ly/49xTdVa
Cell Reports Methods

📢 Registration open for the 'RNA Modification and Processing' conference!

Register here: trr319-rmap.de/symposium/

Organised & funded by: RMaP - TRR319, At the Helm, FrancescaTuorto, König Lab, DFG public | @[email protected], IMB Mainz

One week left for early bird registration to the international 2nd Chemical Biology Ireland Conference (22-23 July). Check our amazing list of speakers and join us in vibrant Galway for 2 days of great Science! #ChemicalBiology
universityofgalwaycbic.clr.events/event/134280:c…

Join us! We are looking for a new team member (PhD student) with strong background in organic chemistry.

Organic chemistry meets #DirectedEvolution
Highly interdisciplinary & passionate research group

🙏RETWEET (We want to recruit internationally)

uni-bielefeld.hr4you.org/job/view/3249/…

Enjoying the fantastic lecture of David Leigh at the Dutch Symposium of Organic Chemistry #DSOC .

confirmed speakers: CarreiraGroup Dorota Gryko Nevado Group SchindlerLab Oliver Wenger Leonori Lab BonifaziLAB Andrey Klymchenko 🇺🇦 Paolo Melchiorre Ritter Lab Noel Research Group König Lab Andrea Rentmeister Gasser Group, Kirsten Zeitler, GilmourLab

Straight to the face 👊
Nice collaboration with Ken Houk and Dennis Svatunek! Small cycloalkane fusions enhance the cycloaddition reactivity of dibenzocyclooctynes (especially towards tetrazines 🩷)
Many congrats to Toni and Dennis! 🧪💻🧑‍🔬🧑‍💻
#bioorthogonal
doi.org/10.1039/D3SC05…

2',3'-Protected Nucleotides as Building Blocks for Enzymatic de novo RNA Synthesis (Marcel Hollenstein and co-workers) onlinelibrary.wiley.com/doi/10.1002/ch…

Why can RNA only be linear or circular? It can be branched! We made multi-tailed mRNA, and we had fun! Here is our story led by brilliant graduate student Hongyu Chen: rdcu.be/dB7ck and his cartoon illustration👇MIT Chemistry Broad Institute

We stabilized our FlashCaps with a methylene group between the β and γ phosphates. 💪 You can read about our Medronate-FlashCaps 👇 Thanks to all coauthors Florian Weissenböck Nils Klöcker 🙏 and European Research Council (ERC)
pubs.acs.org/doi/full/10.10…

Orders of magnitude higher activity, for multiple substrate, in a single enzyme engineering step?

Efficient transferase engineering for SAM analog synthesis ... towards selective alkylation with engineered enzymes Kai_Schuelke Marc Garcia Borràs #FOR5596

doi.org/10.1002/cbic.2…

It was a wonderful experience to prepare and give lectures about SAM analogues and what you can do with them. Thanks for the opportunity and chapeau to all partcipants from diverse scientific backgrounds. And of course, always a pleasure to experience 🇨🇵🥖🥐🗼😊

Thank you @DiePresse for this nice article about our work Universität München and previously Universität Münster 😊 Always happy to stay in touch with home (and had not realized that I spent most of my life abroad).

Ein Grundbaustein des Lebens diepresse.com/18255640/ein-g… via Die Presse

What a pleasure to speak about controlling RNA function by light to such an interested audience. Thank you for the opportunity, the great discussion and the delicious lunch Etheve-Quelquejeu Team 😊

Interested in mRNA vaccines? Chemical modifications? a fully funded postdoc position? Then you may want to have a look at our add:
research.pasteur.fr/fr/job/increas…

Great kick-off meeting with interesting sciene and nice colleagues 😊 Want SAM more 😉🤓

last chance to apply for PhD study in my group - check the available projects

I am thrilled to share our new paper published in NatureStructMolBiol (Brito Querido et al., 2024). #CryoEM structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A.
#Ribosome #mRNA #Science
nature.com/articles/s4159…

A fireworks of nucleic acid chemistry 🎆👌Perfect start into the final day of #ChemBio2024 .