What are the functional roles of 3D genome organization? Our paper in nature led by Prashant Bhat demonstrates how dynamic 3D genome organization around nuclear speckles plays a crucial role in regulating mRNA splicing efficiency. rdcu.be/dHkez

We are delighted to share the #tyrosine The Kinase Library, now in nature: nature.com/articles/s4158…

Tyrosine predictions and enrichment analysis are now available: kinase-library.phosphosite.org

#TheKinaseLibrary #KL #part2

🧵

1/9

Our 2nd annual “night at the museum” organized by the University of Utah DASL group was a great success! Students delivered TED format talks to a general audience NHMU, funded by CZI Science as part of a science communication workshop I run.

Mitochondrial complex I construction relies on a patchwork of poorly defined 'assembly factors.' In work led by Andrew Sung, we used deep mutational scanning to elucidate NDUFAF6 function and predict variant pathogenicity.
Taylor Lab
Charlotte Alston
nature.com/articles/s4225…

Feng Xiao spent 8 years trying to find out how cardiomyocytes disassemble their sarcomeres during mitosis. Grateful for her dedication and to Nguyen Ngoc Uyen Nhi who took on the difficult task of finishing this project. Thankful for our wonderful collaborators. bit.ly/3UP82hO

Could not be more delighted to present our work investigating how over 220,000 complex and molecular trait-associated genetic variants affect transcriptional regulation using massively parallel reporter assays!
biorxiv.org/content/10.110…
See below for a 🧵. 1/n

CoQ10 is a very hydrophobic molecule with poor bioavailability. In this new study, led by Laura Steenberge, we build on prior work to show that the much more soluble CoQ4 is sufficient to rescue diverse CoQ functions and can be targeted to mitochondria.
doi.org/10.1016/j.jbc.…

Excited to share the lab's latest pre-print 'Paralogue-specific degradation of the lysine acetyltransferase EP300.'

biorxiv.org/content/10.110…

We are excited to share a new preprint from the lab! Rab6 is a central regulator of the Golgi, important for trafficking and autophagy. Ryan Feathers used #cryoEM to determine the structural basis of the Rab6 activation process. (1/9)

We are hiring! Multiple faculty positions are available at the UArizona Sarver Heart Center and Division of Cardiology at UA College of Medicine – Tucson. Physician Scientists, Scientists, Clinical Researchers and Clinical Cardiologists. Message me or email me at [email protected] for more info. Plz repost.

Very happy to share our #preprint revealing the early events triggered by ferroptosis at the ER-mitochondria contact sites, apical orchestrators of lethal lipid peroxidation driving ferroptosis. Thx to Agostinis Lab and all our collaborators! The ScorranoLab Geert Bultynck 🇺🇦 #KaganLab

“I suspect that scientists have failed because they approach the problem of implementation of knowledge gained as a scientific matter. We did not realize that was rather only in part scientific, but at least in equal part a political and social problem”-Irving Selikoff 14/14

I am excited to share our preprint 'Identification of Fasnall as a therapeutically effective Complex I inhibitor.'

biorxiv.org/content/10.110…

Several things from inside 👇

We asked a question: What happens with the polar metabolome of cancer cells when fatty acid synthase (FASN)…

16” of new snow on May 6. It’s not over until we say it’s over 😤 #SnowbirdSurfSeason

👉 HHMI is seeking creative and innovative early career faculty for our Freeman Hrabowski Scholars Program. 🧬

We launched a nationwide competition to select up to 30 early career science faculty to join the #FHScholars 2025 cohort.

📆Deadline 5/15: hhmi.news/3UA4Gz0

Tonight on #MitoMonday we briefly highlight the life and works of an extraordinary scientist who co-discovered a treatment for tuberculosis, and helped establish federal asbestos regulations, Dr. Irving Selikoff. #LateNightWithTheRutterLab

V happy to share my work in DeBerardinis Lab Children’s Research Institute at UT Southwestern from past 2 yr! In equal collab with Tony Rodrigues, Dwendscheck (dwendscheck.bsky.social), Jorge Azevedo’s lab, Warscheid lab, we have discovered PEX39, the first human peroxisomal biogenesis protein (peroxin/PEX) found in > 20 yr! biorxiv.org/content/10.110…🧵

Really happy to share this pre-print!

Some really interesting findings and hopefully after review it can become a useful resource for the metabolism field!

Thanks to Peter Mullen for making it happen, plus a load of fantastic collaborators! Lyssiotis Lab Brian Kennedy

Excited, the first batch of MS/MS from ~ 50,000 molecules. Free to download and use. 12,000 drugs -pos and neg mode. Others include Bile acids, n-acyl lipids, natural products, flavonoids etc. Good start. We will update periodically in GNPS - UC San Diego. external.gnps2.org/gnpslibrary

So grateful to be part of the ECOG-ACRIN Cancer Research Group Edith P. Mitchell, MD Health Equity Travel Scholars! Thank you ECOG-ACRIN Cancer Research Group for the invitation to honor the memory of a great mentor and leader Edith Mitchell, M.D..