In this preprint biorxiv.org/content/10.110… with @sindri_e we compared seven widely used methods for batch correction of single cell RNA-seq data. We found that all but one of the methods introduce batch effects when there are none. 1/N

Wow! The 'Elements of Successful Grant Applications' is a masterpiece - #MustRead for all researchers. It is a a roadmap to grant funding inspired by Euclid's famous 'ELEMENTs'. It is so good I decided to summarize it in a thread 👇🏼
#ElementsofFunding
pnas.org/doi/10.1073/pn…

Ever considered measuring genetic variant effects with prime editing but hesitated due to low and variable editing? Last month, 3 papers showed that large-scale screens can work 💪. A 🧵 comparing the papers of the Francisco J. Sánchez-Rivera lab, the Britt Adamson lab, and Greg Findlay

Elements of successful NIH grant applications | PNAS pnas.org/doi/10.1073/pn…

Wow! a brilliant article from the grant writer's perspective as well as the reviewer's perspective. A must-read for everyone in academia.

My lab is hiring postdoctoral researchers. Passionate about scientific discovery? Looking to join a dynamic, diverse and welcoming team? Intrigued by genome function and stability deregulation in cancer? This may be a great opportunity for you. #CancerResearch

🗞️ IN THE NEWS: Dr. Shyam Sharan (Shyam K. Sharan) and his team's work were featured in this article by The Scientist, which explores how the use of Mammary organoids is teaching us about #BreastCancer development.
👇👇👇
the-scientist.com/growing-milk-s…

Thanks to The Scientist for covering my work with Shyam K. Sharan NCI Center for Cancer Research Frederick National Laboratory on mammary organoids Developmental Cell the-scientist.com/growing-milk-s…

Our latest from The Crick, now on bioRxiv:

biorxiv.org/content/10.110…

Michael Herger (@HergerMichael) and Christina Kajba jointly led development of a new prime editing platform for testing large numbers of human genetic variants.

Excited to share our new article: Establishing conditions for the generation and maintenance of estrogen receptor-positive organoid models of breast cancer | Breast Cancer Research | Full Text …ast-cancer-research.biomedcentral.com/articles/10.11…

🚀Discover the transformative impact of #organoid technology on #mammarygland biology across different mammalian species 🐁🐄👩‍🔬 & the exciting possibilities for regenerative medicine, #breastcancer research & lactation studies in article by Gat Rauner. shorturl.at/kmE69

I am pleased to share the final version of our Human Breast Cell Atlas with MarioniLab now out Nature Genetics. There are important new additions, which I will leave to Sara Pensa and Austin Reed to mention👇 . Couple of points i want to highlight 👇:
nature.com/articles/s4158…

Trying to find undifferentiated cells or cells with high plasticity in your scRNA-seq data.. try CytoTRACE2.

My friend, the artist and ecologist Sambita Modak's art is being displayed at Aurelec, Auroville, Pondicherry between 15th March to 6th April. I would urge everyone to drop everything you're doing and go attend the exhibition. You can find Sambita on Instagram @wrong_tool_i

Want to hear about the latest updates/new techniques in single cell and spatial genomics? Check out the full agenda for our Single Cell Genomics Day on Friday, 3/29. All talks will be live-streamed (no registration required) at satijalab.org/scgd

In our new preprint, we show that CRISPR activation of of just two endogenous regulatory elements is sufficient to self-organize embryonic stem cells into spatially-ordered embryonic patterns. biorxiv.org/content/10.110… #crispr

SWATI portal launched on International Day for Women and Girls in Science. You can join at
bit.ly/JoinSWATI
And here are some of my students from an ‘all girls’ lab who were there…

👏 CELEBRATING CCR CAREERS: Jonathan R. Keller, Ph.D., an experimental hematologist who discovered interleukin-3 (IL-3) and explored the factors that give rise to leukemia, announces his retirement.

➡️ Read more: go.cancer.gov/MFMW6cl