2 postdoc positions in my lab @ King's College London CDN | King's College. Please apply if you'd like to understand neural circuits of cognition in mice, using 2p, 3p imaging, holographic optostim, flexible behaviour & more! Please RT!
Links kcl.ac.uk/jobs/087206-re…
khanlab.net

Attentional modulation of secondary somatosensory and visual thalamus of mice biorxiv.org/cgi/content/sh… #biorxiv_neursci

Representational non-drift
A persistent prefrontal reference frame across time and task rules nature.com/articles/s4146…

I am excited to share our joint work with Ivo Spiegel on developing a ‘permanent marker’ for functionally defined neurons. A big shout-out to Carlllllllllllllllllllllllllll, Bovey Rao, Stephanie Herrlinger, Tiberiu Mihaila and others in the lab and to the Spiegel group!
biorxiv.org/content/10.110…

I'm delighted to share that my debut book, PLAYING WITH REALITY: HOW GAMES HAVE SHAPED OUR WORLD will be out June 18 from Riverhead Books .

Now on bioRxiv, a long-term collaboration between Alex Wang and Katie Ferguson on somatostatin interneuron development, with gorgeous synaptic data from Michael Higley 🧠🌈🔬 and Jyoti Gupta. SST cells in 🐭V1 have a unique developmental window right after 👁️opening!

This is pretty amazing: a single hominoid-specific genetic change leads to loss of the tail. What an incredible phenotype!

Come and join our lab at the University of Edinburgh! Link to the job posting in the comments below.

If I could snap my fingers and change everything, here is what I would do:

1) Have all publishing happen on a single, consolidated, 100% subsidized 'preprint' platform that publishes, formats, disseminates and archives all works of science with zero cost to authors or users.

Come and work with us in Sunny London! We have up to two postdoctoral positions to investigate the cellular, circuit and synaptic basis of how internal states such as hunger and thirst can be used to guide behaviour. Apply until Feb 8th here: ucl.ac.uk/work-at-ucl/se…

Simultaneous, cortex-wide and cellular-resolution neuronal population dynamics reveal an unbounded scaling of dimensionality with ... biorxiv.org/cgi/content/sh… #biorxiv_neursci

It was great fun to work on this preprint with Dr. Robert Lees ibianco Rob Campbell Natalia Orlova 🇺🇦 Darcy Peterka @labrigger Dimitri Yatsenko Che-Hang Yu & Adam Packer.
Hope this helps many people to characterise their 2p microscopes biorxiv.org/content/10.110…

A new study by Petr Znamenskiy, Tom Mrsic-Flogel, and colleagues present findings that overturn a decade-long idea that inhibitory neurons provide blanket normalising inhibition, showing that for PV+ inhibitory neurons this is not the case. Read the story: sainsburywellcome.org/web/blog/revea…

A beautiful interplay between SST interneurons and PV interneurons control de transition from correlated to sparse coding in cortical dynamics during early postnatal development. Beautiful work from superstar Laura Laura modol vidal biorxiv.org/content/10.110…

How do neurons integrate excitatory and inhibitory inputs in a developing circuitry with remarkable neuronal diversity? If you are interested, do not miss our latest paper preprint in BioRxiv by my exceptional postdoc Tim Kroon in simply Lab, #synapses , #interneurons , #cortex .

My latest #neuro #visualization :
An intuition pump on connectivity in the #brain
~75K #neuro ns in the #MICrONS mm³.
I/O segregated by layers, function is columnar; the cortical column is the unit of cortical computation.
A typical #pyramidal cell has over >10K input #synapses .

Finding brain connections is slow. So we present Optomapping!

With laser-activation of single inputs + postsynaptic patch, 100s of connections can be rapidly examined.

Led by Jesper Sjöström @pjsjostrom.bsky.social ‘s long vision, spearheaded by the talented & persistent Christina 😬. Glad to be part of this

Cholinergic input to mouse visual cortex primarily signals a movement state signal, with virtually no activation in response to visual stimuli or prediction errors. biorxiv.org/content/10.110…

Cutting it a bit fine, but it's that time again: The Spike's review of the year in neuroscience

2023: A Review of the Year in Neuroscience link.medium.com/7lJ0d4aTWFb

Enjoy!

including Dud{man,Lab}🇺🇦 Sandeep Robert Datta nic tritsch 🇺🇦 🏳️‍🌈 #BLM Jesse Goldberg Wei Ji Ma and many more

How does the brain implement and switch between different behavioural strategies, such as explore, exploit or disengage? Remarkably, a small nucleus in the midbrain can do it all! A new, exciting direction for my lab led by the amazing Mehran Ahmadlou: biorxiv.org/content/10.110…