This drug class is exceeding all expectations, well beyond weight loss, with new clinical trial data this week for heart disease and #Parkinsons
A rundown and where we're headed in the new Ground Truths (link in profile) and a companion podcast w/ Daniel J Drucker

The GLP1 one story continues to be incredibly fascinating. Eric Topol did a great review here: erictopol.substack.com/p/a-big-week-f…

New and worrisome: common household chemicals can directly harm oligodendrocytes, brain health
nature.com/articles/s4159…
Nature Neuroscience Paul Tesar CWRU School of Medicine Quarternary ammonium compounds (disinfectants) and organophosphate flame retardants implicated from organoids and expt'l models

Our notifications are blowing up with basketball tweets, but we are the Yale molecular biophysics and biochemistry account! You might want to tag Yale Men's Basketball instead 🏀

Boola boola!

Like so many other drugs frequently used in medicine, the mechanism of action for metformin is not understood. A new report today highlights the gut-brain axis for its suppression of appetite
nature.com/articles/s4225…
nature.com/articles/s4225…
Nature Metabolism

Exome sequencing is a genetic testing method that analyzes a portion of your genome or total DNA, called the exome. The exome represents the protein-coding regions of genes, which contain the majority of known genetic variants associated with disease risk. #TotalHealthTuesday

You may be surprised, but twitching in your sleep doesn’t necessarily mean you’re having nightmares. Scientists have identified a genetic marker in the BTBD9 gene that impacts your sleep movement. Learn more here: 23and.me/490FYw1

Exciting times in biology! nytimes.com/2024/03/10/sci…

Sweetened drinks linked to atrial fibrillation risk newsroom.heart.org/news/sweetened…

Great podcast talking about genetics in drug discovery, featuring Matt Nelson. “Scale matters in the genetics of complex disease. With very few exceptions, there is no alternative to scale.” podcasts.apple.com/us/podcast/the…

Phenomenal CERSI summit in SF. Innovations in reg science. From med misinfo, debates on direct 2 consumer ads to FDA chiefs chat, the insights are 🔥 - Triangle CERSI 2024
UCSF-Stanford CERSI U.S. FDA Dr. Robert M. Califf Scott Gottlieb, MD Duke Clinical Research Institute Duke-Margolis Dr. Janet Woodcock Adrian “WE NEED RCTS!” Hernandez

We should all be talking about this. npr.org/sections/healt…

Congratulations on the approval of the first CRISPR based therapy! So many patients are going to benefit thanks to this technology and the work done to develop it! Doudna Lab Vertex Pharmaceuticals

Prioritize prevention with 23andMe+ Total Health™, our new health membership that combines exome sequencing, blood testing and direct access to clinical services.

Interesting window into 23andMe's efforts in drug development: efficacy data on the company's cancer immunity.

52% had stable disease, with median treatment duration of 18.6 weeks. But immunotherapy cohorts can be hard to read.

What do you think?

investors.23andme.com/static-files/1…

Our paper, showing PRS are predictive of incident disease - not just classifiers of existing disease: medrxiv.org/content/10.110…

Congratulations ⁦Katalin Kariko⁩. What an amazing demonstration of perseverance. wsj.com/health/after-s…

Jimmy Buffet was a great entertainer who helped us hear the music of life. He’ll be sorely missed, and I hope he‘s found that lost shaker of salt. 🎶 🏝️

I’ve had the pleasure of meeting a lot of extraordinary people in my life, but Jimmy was extra special. He had such a wonderful appreciation for life. You had some magical DNA Jimmy Buffett even if you weren’t related to Warren.
cnbc.com/2018/02/08/war…

So proud of the @23andme team for working with FDA to pave the way for making this important risk information more available to a more diverse population.
investors.23andme.com/news-releases/…