A MGH Neurosurgery team including Drs. Bommareddy (@Praveen_IO) and Saha illustrate that an an oHSV expressing IL-2 called G47Δ-mIL2 is efficacious, stimulates antitumor immunity against orthotopic glioblastoma (GMB), and may also target GBM stem-like cells.
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The 3rd In Vivo Cell Engineering & Gene Editing Summit is a once-a-year opportunity to connect with key players and delve into all aspects of 𝘪𝘯 𝘷𝘪𝘷𝘰 cell and gene therapies to stay ahead of the curve.

Use code 'MP4743410' for 10% off registration!
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Researchers at Xuzhou Medical University designed bispecific BC19 CAR T cells targeting BCMA/CD19 and evaluated antimyeloma activity in vitro and in vivo, finding them feasible, safe, and effective in a Phase I/II clinical trial.

go.nature.com/3UaYz2W

Wuhan University (Wuhan University) reveals that USP8 deubiquitinates glutathione peroxidase 4 (GPX4), safeguarding it from proteasome-mediated degradation and enhances the efficacy of anti-PD-1 #immunotherapy in mouse tumor models. | PNASNews

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🔎 Scientists at Southern Medical University in China report a novel IL-21 receptor that programs powerful T cell receptor-engineered T cells and can avoid side effects induced by IL-21 systemic utilization.

go.nature.com/3UbB3md

📚 The roles of 'scientist' and 'storyteller' do not need to be diametrically opposed to one another. Developing a strong narrative is as integral to science writing as it is for any other form of communication. #SciComm

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Enabling standardized manufacturing and having clear efficacy and pharmacokinetic characteristics are prerequisites for ensuring the effective practicality of #CART cell therapy drugs.

Authors discuss approaches to control CAR-T cells' behavior in vivo:
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In vitro and in vivo results, including patient-derived xenograft studies, collected by Oslounivsykehus scientists including Dr. Casey, demonstrate that the CA125 domain of MUC16 represents an excellent target for treating MUC16-positive malignancies.

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Researchers are attempting to determine how to best target and leverage effector cells of interest and optimize design elements of the viral vectors, nanoparticle, and nucleic acid formulations for #CART .

Dr. Lauralie Short at BC Cancer and team review:

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New #JITC article: Phase 1 study combining elotuzumab with autologous stem cell transplant and lenalidomide for multiple myeloma bit.ly/3JjMsvl Donna Catamero Hearn Jay Cho MD, PhD

🐎 Nanjing University scientists engineered a Cellular Trojan Horse, named MetaCell, which uses live neutrophils to stably internalize thermosensitive liposomal bimetallic Fe-Cu metal-organic frameworks.

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Connect with 50+ expert speakers at the 6th Annual Allogeneic Cell Therapies Summit to deliver affordable, accessible, and universal cell therapies to patients across the globe.

Secure your pass today: ter.li/8f54hc

What all women want starts with a p and ends with an s.

The startup 'Somite. ai' aims to improve the lives of millions of people by leveraging AI 🤖 to produce human tissue for cell therapies, striving to be the 'OpenAI' of stem cell therapy, reports Forbes.

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A recent #ClinicalTrial analyzed by Dr. Sumanta Pal at City of Hope and team demonstrates the first complete response in a patient with #RenalCellCarcinoma , reinforcing the potential benefit of CAR T cells in the treatment of solid tumors.

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Beautiful work Evan!! Even though critics always say mice aren’t humans, here’s another fantastic example of how foundational work in murine T cells led to a significant translational finding. Go memory T cells. Congrats!!

Researchers at Shanghai Jiao Tong University (Shanghai Jiao Tong University) have developed a design concept for CAR-T cells that is independent of antigen specificity, and provides an alternative approach for improving the efficacy of CAR-T cell therapy.

📖 Learn more: bit.ly/3vMgDs3

📢 New in PNASNews!

Researchers at Kyoto University have identified proliferative off-target cells, termed proliferative #mesenchymal stem cells, that emerged unexpectedly after the implantation of iPSC-derived pancreatic #IsletCells .

🔗: bit.ly/3VT4PP9

Congrats to the lab of Dr. Ian Blair at Penn Medicine on their new Scientific Reports paper! 🎉

They investigated the expression and processing of mature human frataxin after #GeneTherapy in mice. 🐭

Read the study: go.nature.com/3U8dPPb