Opinion piece from Ik Shin Chin and I on germline markers of toxicity and response to immune checkpoint inhibitors #ICIs #CPB #immunotox @Immuno-Oncology Insights
insights.bio/immuno-oncolog…

First post pandemic #ArthurThomson lecture @unibirm_MDS entitled Variability is the law of life by Professor Sir Munir Pirmohamed Munir Pirmohamed Sir Professor Munir Pirmohamed who I had the great pleasure hosting Institute of Cancer and Genomic Sciences (UoB) this morning

Delighted to share that Ik Shin Chin passed her PhD viva Institute of Cancer and Genomic Sciences (UoB) earlier this week. Momentous day for her and the Palles lab -she is PhD number one! Thanks to examiners Marc Haber مارك and David Church & chair John Halsall & of course @CRUKBirmingham & Midlands for funding this clinical PhD!

Today we remember Dame Deborah James ( Deborah James ). She was an inspiration, and we’re proud to call her our patron and friend. She was a beacon of light whose legacy will continue to save lives for many years to come💛

Read our tribute to Deborah 👇

Really shocked and saddened to hear that the #NCRI is being wound down. I personally have benefitted from the networking opportunities created by the NCRI and always admired all that they did to support cancer research in the UK. What now??? ncri.org.uk/ncri-is-windin…

A visual reminder that armed immune cells have a hard job accessing tumour cells in the plenary talk at #OF23

Reminder to test for #dpyd low function/no function alleles when treating with 5FU based treatment during this mornings Genomic symposium at #of2023 . The need to add additional variants to panels to continue to improve safety was also highlighted!

Practice changing results from AIIMS, New Delhi. Topical diclofenac reduces grade 2 + Capecitabine induced HFS. Interesting that lower HFS was seen in placebo group too. Only 15% compared to 30%. #livingwithandbeyondcancer . Something to implement Birmingham Cancer Research UK Clinical Trials Unit University Hospitals Birmingham ?

Superb discussion by Kara Maxwell at #ASCO2023 regarding germline testing in lung and indeed all cancer patients

My #owncup is feeling lonely at #ASCO2023 . I know #reuse isn’t the theme of this conference but so easy to pack your #owncup for #asco2024 !

Downtown Chicago with #ASCO23 in town. Is this the only time you hear “DNA sequencing talk” in every restaurant, bar and street corner?

📢Watch our #BBCLifeline Appeal
📺BBC One Sunday 29th January 1.55pm
We are EXTREMELY excited to be shouting about the AT Society on TV!
Join Louise Minchin as she explores how the AT Society is changing lives.
👉bitly.ws/zgYv

I am hosting this ICGS seminar today at 2pm on zoom! Please come and listen to the great work coming out of the quantitative genetics Gusev lab: twitter.com/ImmunologyUoB/…

What an absolute mess.

EU blocks UK scientists from €95bn Horizon research programme ft.com/content/96524f…

The Russian invasion of Ukraine has destroyed the Ukrainian infrastructure making it impossible to perform biomedical research. It is also creating serious problems for the scientific enterprise in Russia. I feel the urgency to help brilliant scientists from these 2 countries 1/3

Scientists report a multi-organ tumor predisposition syndrome caused by bi-allelic LoF germline variants in MBD4. Their findings advocate for the inclusion of MBD4 in genetic testing for polyposis & multi-tumor phenotypes.

Learn more in AJHG: bit.ly/3LtzfzC

When you are co-module lead for the first time and you find your colleague has made an easy to use app to save you some number crunching for WAMS! Thanks Deena M.A. Gendoo

Thank you Institute of Cancer and Genomic Sciences (UoB) for this award. Shame COVID got in the way of attending #ICGSAwayDay . Link to the paper that was recognised: nature.com/articles/s4158…. Thanks again to Dr Sara Galavotti, Philip Robinson Tim Coorens and all other co-authors.