I enjoy video games because they let me live out my wildest fantasies, like being assigned a task and then completing that task.

In my review, I made a list of much science that happened bc AlphaFold2 code was released. I suggested that so much science will not happen if AlphaFold3 code is not released (or not with AF3 itself). We've made ~100k models with AF2 code. How could we use a server for all that?

Demis -- I think AlphaFold3 is really exciting. As Reviewer #3, I got great results from the server. I tried hard to get nature to urge you to release the code but was unsuccessful. I did not get it for re-review so I don't know if you responded. So why no code? Google DeepMind

Magdalena Skipper Wondering if you might comment on the decision to publish in your venue with the disclosed restrictions given:

“A condition of publication in a Nature Portfolio journal is that authors are required to make materials, data, code, and associated protocols promptly available to…

I'm excited to share our latest ARIA programme thesis -- a plan to deepen our understanding of approaches that could avert or delay dangerous climate tipping points👇 /1
x.com/ARIA_research/…

Today we announce the submission to #ClinVar of >32,000 variants evaluated for the return of hereditary disease risk in the AllofUsResearch cohort. Its wonderful to return value to those who contribute their data to biomedical research! More details here: allofus.nih.gov/news-events/an…

Far-UVC could save the day in the next pandemic if we make it cheap! Read this excellent piece of work by Jasper Götting and viv on how to get there. Lots of caveats in the report but this is Twitter :)

Never ask a man his salary, a woman her age, or an Anglophone country how it’s housing policy is going.

Some economists tried to reproduce the results of 67 economics papers and they pretty much couldn't do it:

Even with help from authors, only half of papers ended up being reproducible, and this was still a problem at journals with required reporting of code and data.

I told a grad-student co-author 'try to imagine me as the guy from 'Memento' who can't remember anything & needs clues to pick-up the thread on projects' and they said 'I believe you, because you already used that memento analogy'

I am excited to announce the launch of Renaissance Philanthropy, with a phenomenal team including Kumar Garg. Our goal is to help foundations and philanthropists promote a 21st century renaissance, fueled by advances in science, technology and innovation.

After 20 years and 42 days, Illumina's patent covering DNA microarray normalization, clustering, and genotyping, together known as Illumina GenCall, filed on March 24th 2004, has expired patentcenter.uspto.gov/applications/1… 1/8

Generating (Somewhat) New Biology with AI 🧬

Some notes and thoughts on using protein language models for Digital Evolution.
centuryofbio.com/p/digital-evol…

It pains me to see facile critiques of GWAS on here from our clinical/biostats friends while the many actually good reasons to be critical of GWAS get little attention. So here's a thread on what GWAS does, what critics get wrong, and where GWAS is genuinely still lacking. 🧵:

Stepping into a hospital right now, knowing what I now know about airborne spread, gives me the same feeling as opening up a 19th century novel and seeing the leeches come out. It’s stunning that basic science is being ignored

I absolutely love examples of human genetics informing drug adverse effects. A fascinating new example I learned today, thanks to Ben Williams for pointing to me.

Many would be familiar with the immune checkpoint inhibitors used in the treatment of many cancers…

Our review paper on 'Genome assembly in the telomere-to-telomere era' published online in Nature Reviews Genetics. It amazes me how much assembly has progressed in the past four years – often ~100X improvement in contiguity and base accuracy and with haplotypes and hard regions resolved!

Two new chapters from my open-access textbook in human population genetics are now online:
- Population structure: I. Ancestry estimation
- Population structure: II. More about admixture
web.stanford.edu/group/pritchar…

Genetic risk shouldn't be considered in isolation. Our work led by Buu Truong shows how clinical risk factors and a coronary artery disease polygenic risk score interact to optimally inform coronary artery disease risk. sciencedirect.com/science/articl… Med by Cell Press

gnomAD 4.1 is now live! This release fixes the AN issue in #gnomAD v4.0 & adds 2 new functionalities:
1) Joint AN across all called sites in exomes and genomes
2) A flag indicating when exomes and genomes frequencies are highly discordant
Learn more at broad.io/gnomad_v4-1