Functional and structural insights into activation of rat TRPV2 by weak acetic acids – endogenous agonists acting via permeation through the cell membrane
Andreas Leffler, Vera Moiseenkova-Bell and collaborators
embopress.org/doi/full/10.10…

Happy to see this well-deserved recognition for our former Advisory Editorial Board member, who helped shape our journal's profile in the field for many years!

Presenting metabolomics analyses: what’s in a number?
As part of a methods advice series, Meiser and Frezza highlight frequent pitfalls and offers guidance related to designing, processing, and communicating metabolomics analyses
JMeiser_lab FrezzaLab
embopress.org/doi/full/10.10…

How do type-I interferons & IFN𝛄 induce different immunological responses?
Thomas Decker et al find similar initial transcriptional programs, which however diverge at later points due to differential engagement of ISGF3 and IRF1 transcription factors
embopress.org/doi/full/10.10…

Krebs cycle succinate-CoA ligase SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression
embopress.org/doi/full/10.10…

Just one week left to conference register for an emerging topic in Plant Biomechanics in Singapore! 🇸🇬We will explore interdisciplinary insights from single molecule, complex, to tissue level, blending advanced imaging, mechanical modeling, physiology, and plant pathology. 🍀🌲🌿

A nanobody toolkit for tracking or blocking nuclear pore complex (NPC) biogenesis identifies a checkpoint linking assembly of the NPC scaffold to formation of the Np98-dominated permeability barrier

Dirk Görlich and coworkers
NPC-aficionado MPI for Multidisciplinary Sciences

embopress.org/doi/full/10.10…

Common regulators of dysfunctional “anergia” and “exhausted” natural killer cells can be targeted to restore cytotoxicity and anti-tumor activity
Mira Barda-Saad and coworkers
embopress.org/doi/full/10.10…

The EMBO Global Investigator Network supports group leaders setting up their laboratories in #Chile , #India , #Singapore or #Taiwan . Apply by 1 June:

embo.org/funding/fellow…

#lifesciences #funding

Non-vesicular phosphatidylinositol transfer plays critical roles in defining organelle lipid composition
Tamas Balla NIH and coworkers
embopress.org/doi/full/10.10…

Transcriptional rewiring of an evolutionarily conserved circadian clock:
Luis Larrondo Luis F. Larrondo and collaborators show that basic circuit topology can be dramatically changed, while still yielding a functional semi-synthetic clock
embopress.org/doi/full/10.10…

Apicomplexans that undergo binary division like Toxoplasma DO have G2 cell cycle phases; controlled by CDK/cyclin pair Crk4-Cyc4 & a new inhibitor of reduplication
Lauren Hawkins, Elena Suvorova et al USF Health Medicine
#RefereedPreprint c/o Review Commons
embopress.org/doi/full/10.10…

What is the essential role of METTL16-mediated RNA m6A modification in early embryonic development?
IGF2BP1-mediated stabilization of mRNA for the MYBL2 transcription factor drives G1/S progression in hematopoietic stem and progenitor cells
embopress.org/doi/full/10.10…

Cryo-EM of native γ-TuRC-capped microtubules from frog egg extracts shows transition from open to partly closed conformation, with local misalignments in the RanGTP-dependent nucleation pathway
Elmar Schiebel, Stefan Pfeffer et al ZMBH - Center for Molecular Biology Heidelberg Uni Heidelberg
embopress.org/doi/full/10.10…

Opening of the most exciting meeting in my cal: EMBO EMBO_YIP global investigators NTU Singapore - impeccable arrival straight off flight 3' before opening by chair of biosci. school, Kanaga Sabapathy: nice reminiscences of our join work on JNK-SAPK signalling 30 years ago. EMBOPress

TEAD2 initiates ground-state pluripotency by mediating chromatin looping
embopress.org/doi/full/10.10…

Identification of histone H3 chaperone DNAJC9 as a factor restricting CENP-A mislocalization reveals the importance of proper histone H3-H4 supply in ensuring CENP-A centromere targeting
Munira Basrai Munira Basrai, Colin Hammond Colin M. Hammond and colleagues
embopress.org/doi/full/10.10…

Transcription factor functional interplay: During B-cell activation, BACH2 restricts plasma cell differentiation by heterochromatin-mediated transcript inhibition & by preventing IRF4 homodimer accumulation
Kyoko Ochiai, Kazuhiko Igarashi and colleagues
embopress.org/doi/full/10.10…

TLDc-domain proteins Rtc5 and Oxr1 regulate assembly and subcellular localization of the yeast V-ATPase
Ayelén González Montoro and coworkers
#RefereedPreprint c/o Review Commons
embopress.org/doi/full/10.10…