Very excited to share our latest preprint on somatic mutations in the normal stomach. We found many surprises, incl. hypermutant glands, recurrent somatic trisomies and a unique landscape of driver mutations. Thread below! biorxiv.org/content/10.110…

Very excited to release Sequoia, our pipeline for phylogenetic tree reconstruction from mutations in normal cells. A detailed description is now published in Nature Protocols! nature.com/articles/s4159…

Very interesting work by Rocio Vicario, Frederic Geissman and colleagues. A microglia clonal inflammatory disorder in Alzheimer's Disease biorxiv.org/content/10.110…

🙏 everyone should read more from Richard Peto, as holiday reading could I recommend his seminal (but not read enough) 1977 book chapter, which IJE was proud to publish the first accessible and corrected version in 2016 academic.oup.com/ije/article/45… I'll refund anyone /cont

I am excited to be part of Quotient Therapeutics as one of its academic co-founders. This is a new Wellcome Sanger Institute and Flagship Pioneering company that aims to greatly scale up and leverage somatic genomics for drug development across diseases. Exciting times ahead!

Following its launch, we have an exciting opportunity for up to three Group Leaders to join Generative and Synthetic Genomics. 🧬

To apply, follow the link below ⤵️
sanger.wd3.myworkdayjobs.com/en-US/Wellcome…

@sangercareers #Recruiting

I am very grateful to the Josef Steiner foundation Universität Bern for their recognition and for their support of our work. And a huge thanks to my team and to the brilliant mentors and collaborators who make our work possible and the journey so enjoyable.

Seeing members of your team spread their wings has to be one of the most rewarding parts of this job. Best of luck, Alex! What a wonderful time this has been. Looking forward to lots of great science from you!

Delighted to announce that our paper on somatic evolution of marine transmissible cancers is finally out in Nature Cancer. For 7 years we investigated a marine leukemia that propagates through marine water to infect cockles in the Coasts of Europe 🤯
1/25 nature.com/articles/s4301…

📢Clonal hematopoiesis driven by mCAs📢What fitness effects do mCAs confer to our blood cells?🩸 How often do they occur? Does an mCA’s fitness correlate with blood cancer risk?🔎Read mine & Jamie Blundell's latest paper Nature Genetics to find out (& more!):👉🔗rdcu.be/dlRRr

The Darwin Medal 2023 is awarded to Dr Peter Campbell for his pioneering contributions to somatic evolution, including some of the most creative and influential studies of evolution in cancer and normal tissues. #RSMedals royalsociety.org/grants-schemes…

I am looking forward to this documentary series by Kat Arney and BBC Sounds on cancer research. This first episode explores why we get cancer, with the help of mummies, dinosaurs, amoebas and naked mole rats.

Massive opportunity alert! Start your new independent lab in any area of experimental or computational biomedicine, in our department at Karolinska Institutet. We offer a 1.1 M€ ($1.2M) startup package, amazing colleagues and a beautiful lab environment. ki.varbi.com/en/what:job/jo…

20 years ago we completed the Human Genome Sequence, a collaboration that would forever change biology research

Here's a personal look back at the humble beginnings of the Project in the UK 🧵

Happy DNA day, everyone! Interesting piece that sheds a subtly different light on likely the most important discovery in biology of the 20th century.

NOW OUT Science Magazine 🧬🐾🤓

“The evolution of two transmissible cancers in Tasmanian devils”

A 🧵 on our deep DNA sequencing dive into the startling genetic history of contagious tumours (1/n)

👇

doi.org/10.1126/scienc…

Today our important study on air pollutants in the promotion of lung cancer has been published in nature led by Will Hill Emilia Lim Clare Weeden Swanton Lab ...Thread below🧵nature.com/articles/s4158…

🧬 Preprint 🧬
Most mutations begin as a change in only one of the two DNA strands.

To see these single-strand precursors of mutations, we developed single-molecule sequencing that achieves single-molecule and *single-strand* fidelity.

biorxiv.org/content/10.110…

🧵⬇️
1/11

Huge congratulations to Prof Matt Hurles (Matt Hurles ) who has been appointed as the new Director of Wellcome Sanger Institute! 🎊
Currently Head of the Human Genetics Programme, Matt will formally take up the Directorship later this year.

Find out more⤵️
bit.ly/3Xq3T26

What’s happening in Israel? Please read and share this thread that I wrote to help clarify the dramatic (and complicated) events that threaten to turn Israel into a dictatorship in a matter of weeks 👇