🛡️ Interferon-induced #EpsteinBarr virus block!

Scientists reported that interferon-induced transmembrane protein-1 inhibited Ephrin receptor A2-mediated Epstein–Barr virus entry into epithelial cells.

👉 Learn more at Nature Microbiology | go.nature.com/3Wbx1NE

🤰 A collaboration between Queen Mary University of London and Zvitambo demonstrates how the #pregnancy immune environment in women with #HIV underlies mortality and immune development in their offspring in a sex-differentiated manner.

go.nature.com/3Q87bpY

Canada will not reach the original World Health Organization's (World Health Organization (WHO)) target of eliminating the #HepatitisCVirus by 2030 and lags in comparison to other developed countries, a new study led by researchers at the University of Waterloo has found.

Are you looking to start incorporating pulmonary organoids into your research? 🔬

Increase your chances of success with STEMCELL Tech's in-house pulmonary #organoid experts in this live virtual training course.
bit.ly/446Zg1B

Drs. Xionglue Wang and Bin Zhu demonstrated that #SARSCoV2 nsp15 preferentially cleaved pyrimidine nucleotides located in less thermodynamically stable areas in dsRNA, such as AU-rich areas and mismatch-containing areas, in a nicking manner.

bit.ly/3UkQAl8

💡 For their April Researcher Spotlight, UMass Chan Medical School highlights the work of Dr. Lee Quinton:

'I am particularly interested in the early events that control #LungInfections —events largely dictated by innate immunity.'

bit.ly/443NYuZ

How does age affect the nasal epithelial response to #SARSCoV2 infection?

UCL Great Ormond Street Institute of Child Health scientists including Dr. Ana-Maria Cujba, Kaylee Worlock, and Maximillian Woodall investigated and found a number of key differences:
go.nature.com/3xOPHs0

A nuanced understanding of myeloid C-type lectin receptors' interactions with endogenous and microbial triggers is starting to uncover the context-dependent nature of their roles in #InnateImmunity , reports Drs. Reis e Sousa The Crick and co-authors.

bit.ly/4cYX1Bv

#LongCOVID has been a vexing foe, but new clinical trials mark a new chapter. All seek to address one underlying key question:

Is lingering SARS-CoV-2 virus behind patients’ symptoms?

bit.ly/4cU17uJ

Kick back this Sunday with a review! 📙

Drs. Patricia Vuscan, Mihai Netea, and their fellow co-authors at Radboudumc describe the fundamental mechanisms underpinning #TrainedImmunity 🐕‍🦺 generation and the different cell types that mediate it.

bit.ly/3Jj1MIw

Researchers define enteric coronavirus non-structural protein 2 (nsp2) as a novel virulence determinant, and propose a crucial role of nsp2 in diminishing innate #AntiviralImmunity by targeting TBK1 for NBR1-mediated selective autophagy.

bit.ly/3xwO6qS

💉 Grigoryan (Lilit Grigoryan) and team analyzed the immune responses in healthy individuals after a 2-dose vaccination with a plant-based #SARSCoV2 vaccine with or without the adjuvant AS03, which enhanced the antigenic breadth of B cell memory.

bit.ly/3VZavar

A team including Drs. Avishekh Gautam at Fox Chase Cancer Center and David Boyd at St. Jude shows that a newly developed RIPK3 inhibitor, UH15-38, blocks #influenza A virus-triggered necroptosis in alveolar epithelial cells.

🗞️ bit.ly/3VUINeV
📄 go.nature.com/43WgONR

A team at David Geffen School of Medicine at UCLA including Joey Li (@thejoeyli) and Dr. Timothy O’Sullivan (@osullivanlab) identified myocyte enhancer factor 2C as a master regulator of human NK cell functionality ex vivo.

go.nature.com/3VRw3pi

Researchers are closely monitoring the spread of a worrisome strain of #AvianInfluenza to cattle — and one person — at farms in six US states; the threat to humans is currently low.

go.nature.com/3U87seG

A team of researchers including Drs. Baptiste Pradel (Baptiste Pradel) and Espert Lucile found that HIV-1 exposure led to the rapid LC3B enrichment toward the target cell plasma membrane, in close proximity with the incoming viral particles.

bit.ly/43Rg0Kg

🤔 Curious about the differences and similarities between innate #immune evasion strategies of human #coronaviruses ?

📖 Then check out this #review on innate #immune manipulation strategies employed by the seven human coronaviruses.

👉 bit.ly/49xbwda

🔬 Investigators at Doherty Institute with Drs. Katherine Kedzierska, Lukasz Kedzierski, John Fazakerley, and Isabelle Jia-Hui Foo established a co-infection model of unrelated #viruses causing disease in different organ systems.

👓 Check it out! Nature Communications | go.nature.com/43DmRXM

Investigators used #organoid technology as a new model for studying emerging pathogens and their mechanisms.

They investigated the key 🔑 host-virus interaction patterns of five human #coronaviruses in different human respiratory organoids.

Emerging Microbes & Infections | bit.ly/3xyLusk

Investigators at Fred Hutchinson Cancer Center engineered an anti–PD-1 chimeric antigen receptor 📍 (CAR) to assess the impact of PD-1 depletion on viral reservoirs and rebound dynamics in SIVmac239–infected rhesus macaques.

🔓 Journal of Clinical Investigation | bit.ly/43GxGs5