Today is the last day of abstract submission for Mutations in Time and Space.

mutationmeeting.com

Join us in stunning Edinburgh, 23-25 April 2024, to present your latest research.

I'll be at the GRS and GRC on Mammalian DNA Repair 2023 with a poster on lesion segregation and muliallelism. Come and find me for a chat!

Tomorrow, John Connelly will be sharing his exciting new #pathomics findings:

'Using #MachineLearning and #ComputationalPathology to explain unexpected genomic variation'

Still time to register for this hybrid event RC of Pathologists: web.cvent.com/event/5a353be6…

Our paper, led by Pierre Murat, linking initiation of DNA replication and mutagenesis is out. Congrats to Pierre, Consuelo Perez, guilbaud guillaume & Alastair. Thanks to MRC Laboratory of Molecular Biology and to Simon Reed & Pat van Eijk at Cardiff University & Broken String Biosciences! science.org/doi/10.1126/sc…

Apply by January 9 2023 for our #PhD programme in Human Genetics, Genomics and Disease. Join us in Edinburgh to develop your research career and tackle key problems in understanding how our DNA affects health and disease
Institute of Genetics and Cancer ed.ac.uk/mrc-human-gene…

Are you a graduate level physicist, mathematician, computer scientist or similar that can make a difference in biomedical research? Apply by January 9 2023 for Medical Research Council funded PhD projects for quantitative scientists and join us in Edinburgh! ed.ac.uk/mrc-human-gene…

🧬Are you interested in DNA, mutations, and keeping patients safe?

🧑🏿‍🔬We're looking for a curious, smart, ambitious, team player to join us in October 2023

💊AstraZeneca-Funded PhD Studentship with industrial placement

🗓️Closes: 05 Dec 2022

jobs.cam.ac.uk/job/37892/

Please RT!

A great opportunity...

I have some thoughts on the new eLife policy

Now that I've had a chance to see peoples' questions about eLife - the journal's new publishing model, time for a thread for a thread with some details and answers.

elifesciences.org/articles/83889

..and check out the Alumni from the Edinburgh Scientific Academic Track, who now have open-ended faculty positions. ed.ac.uk/medicine-vet-m…

We are recruiting 30 - yes, that's right, 30! - Chancellor's Fellows to prestigious, tenure-track, research-intensive early/mid-career roles at the University of Edinburgh. Please spread the word!

⏰One week left to apply for the postdoc position Aitken Lab MRC Toxicology Unit Cambridge University

jobs.cam.ac.uk/job/37242/

It took a few years, with a global pandemic and transatlantic relocation in the middle of it. But finally, our manuscript on how UV irradiation remodels the specificity landscape of transcription factors is on BioRxiv biorxiv.org/content/10.110…. Huge thanks to...

🧑🏾‍🔬We're looking for an ambitious, curious, smart, team-playing #postdoc to join Aitken Lab MRC Toxicology Unit Cambridge University

🧬DNA damage, mutagenesis, genome biology, (spatial) genomics

🌍New labs in central Cambridge

🗓Deadline: 24 Oct 2022

📩Apply: jobs.cam.ac.uk/job/37242

Please RT

Discussions at our Bertinoro Computational Biology (of Cancer) meeting #BCB22 were fab. We finished our meeting by summarising these into a 'top 5 open research questions'. I'll tweet the list with hashtag #BCB22 _Qs. We're interested to hear your thoughts (even solutions!)

Earlier this week, John Connelly and Jose Coelho-Lima both gave talks at #ECP2022Basel

Here is John's brilliant talk on 'Predicting genetic variation from quantitative tissue phenotypes using explainable machine learning'

#MachineLearning #DigialPathology #GenomicPathology

Our preprint about the role of POLD1 deficiency in soma and germline mutations is out. biorxiv.org/content/10.110…

Two main findings: surprisingly, POLD1 deficiency has a recessive effect on mutation rate; POLD1 alters mutational spectra to the same degree in soma and sperm

Converging view that nucleotide excision repair is often the source of mutations. Found in bacteria doi.org/10.1101/2022.0…, cancer doi.org/10.1101/2022.0… and building on insights from yeast doi.org/10.1534/geneti…. Houra Merrikh biorxiv adds bacterial and evo. perspective

The UK’s membership to the world’s largest international research funding programme is hanging in the balance over post-Brexit arrangements. 
  
Here’s why science must be kept separate from political negotiations 👇 

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