Collaborators from UTokyo | 東京大学 show that impaired glycosylation of gastric mucins drives gastric #tumorigenesis and serves as a novel therapeutic target. 🎯

bit.ly/4aOtXuL

Fascinating research! Congratulations to the entire team for the publication! 🎊

In a British Journal of Cancer report, researchers share results from their recent investigation of the cytotoxic anti-tumor effect of high-dose, short-term TKI treatment on 5 metastatic #colorectal cancer patient-derived tumor #organoids .

💡 Learn more: go.nature.com/3Qms9l5

Dr. Beno Freedman's team generated a new cohort of base-edited #PolycysticKidneyDisease #iPSCs for 4 clinically relevant nonsense mutations.

Heterozygosity prevents cyst formation and demonstrates base-editing gene therapy. 🧬 Kidney Research Institute ISCRM at UW

bit.ly/3Jd7ADq

Using 🧠 cerebral organoids, human brain explants from individuals without #COVID19 , and post-mortem brain samples from individuals with COVID-19, investigators found that neural cells were permissive to #SARSCoV2 to a low extent.

📖 Nature Microbiology | go.nature.com/3TOJS5t

Investigators including Drs. Laura Dönges and Ivan Martin at University of Basel exposed the 🛠️ engineered osteoarthritic #cartilage organoids to factors known to attenuate pathological features, including IL-1Ra.

Biomaterials | 🔗 bit.ly/4cGRJdZ

Investigators used 🧫 #organoids as a new model for studying emerging pathogens and their pathogenic mechanisms.

🔎 They explored the key host-virus interaction patterns of five human #coronaviruses in different respiratory organoids.

Emerging Microbes & Infections | bit.ly/3xyLusk

Fantastic to see NYSCF—Druckenmiller Fellow Kentaro Iwasawa (Cincinnati Children's) speaking this morning at the ISSCR Cincinnati Symposium about his work using human organoid models and mouse embryos to study early liver specification

What a better way to close out the meeting than with this awesome panel discussion. Thanks to all the organizers, speakers and participants, it was a blast to have ISSCR in Cincinnati. Center for Stem Cell & Organoid Medicine Cincinnati Children's