Pretty cool consequence of AF3 using diffusion is that pLDDT is no longer just for C-alpha but for each atom. RFAA still uses C-alpha pLDDT. Should enable interesting applications for locally refining rotameric states of predictions.

Looks like there'll be no open code for AlphaFold3. At least, there is a server with 10 jobs per day and a server UI that looks pretty much like the Gradio custom component I built for RoseTTAfold-AllAtom #opensource huggingface.co/spaces/simondu…

Announcing AlphaFold 3: our state-of-the-art AI model for predicting the structure and interactions of all life’s molecules. 🧬

Here’s how we built it with Isomorphic Labs and what it means for biology. 🧵 dpmd.ai/3URDiNo

Also holds true for science illustrations... especially when communicating research to the wider public.