السلام عليكم ، رده واجب؟

#薬学ゴロ
#昨日の勉強
モガムリズマブの作用部位と適応症の覚え方
「後でもがいて苦しむ」😵
・あと→ATL(成人T細胞白血病リンパ腫)に適応
・もが：モガムリズマブ
・くるし→CCR4に作用

Interesting paper where the N-terminal domain of GW182/TNRC6 can bind CCR4-NOT via the CNOT9 and not only the C-terminal silencing domain. This might be one of the possible mechanism to transfer information from Ago2 to CCR4-NOT. #argonaute #microrna

onlinelibrary.wiley.com/doi/full/10.11…

$RAPT Will spare Ashwagandha male vitality jokes, wouldn't CCR4 blockage lift breaks on normal immunosuppression function (via Tregs and Th2 cells) - protecting liver specific antigens to be mistaken as foreign antigens? This paper 👇argues Hep B antigens and CC4 link in reverse:

ポテリジオ(モガムリズマブ)
ヒト化抗CCR4モノクローナル抗体

今日、当院で初めて使用されました。
おそらく世界初の「ポテリジェント抗体」であるから「ポテリジオ」と言う名前だと思いました。

ポテリジェントとは、抗体の糖鎖であるフコースを無くすことでADCC活性を約100倍に増大させる技術。

Selective accumulation of CCR4+ T lymphocytes into renal tissue of patients with lupus nephritis eurekamag.com/research/047/3…

MOA animation by KO Studios Biomedical Animation & Illustration of CCR4 Antagonist in Development by FLX Bio, showing the combination treatment of CCR4 Antagonist and checkpoint inhibitors to reduce tumor size.

Explore more: buff.ly/2lnPVkJ

#moa #mechanismofaction #biotech #medicalanimation #3D

'Flower cells' 🌸 in Adult T-cell leukemia/lymphoma.
Positive for CD2, CD3, CD5, CD4, CD25, CD30, CCR4 and FOXP3 (some cells)
Negative for CD7, CD8, ALK
#PathX #PathBoards

CXCR2, CCR4, CD20… specifics PET tracers have been developed and some studies already published/ongoing about their abilities to diagnose/predict active vasculitis… we need to apply this to assess kidney inflammation in #ANCA #glomerulonephritis ! Jason Tarkin #vasculitisBCN2024

📍ปล่อยบัตร 4 Queens ทั้งหมด 3 โซน✨
1.โซนDR7-3,520฿(Seat:F4-F6)*3ที่ติดกัน
2.โซนCCR4-4,020฿(Seat:B8)
3.โซนCL7-4,020฿(Seat:D20)

💌 Dm มาได้เลยค่า ราคายังไม่รวมVat7%🫡
#4QueensConcert
#4QueensConcert Ticket

وجـدان. شاموسكا 🎓 عبدالكريم الحربي جُواهِر الشمرِي. نـجـد خُلود عبداللّٰه آلعنزيّ 🇯🇴. شهد. سامي بن حمد 𝐀𝐧𝐚𝐬. خلود الحربي🇸🇦. سُلطان‌المطيريّ شعور عَزيز Defoe Almaha.. 𝙁𝘼𝙄𝙎𝘼𝙇 𝘼𝙇𝙊𝙏𝘼𝙄𝘽𝙄 🇸🇦 𝐀𝐧𝐚𝐬 𝐀𝐥𝐳𝐞𝐝𝐚𝐧 َ عبود كوكبّة طيب😒.

私が作った天才的ゴロです

りっちゃん（リツキシマブ）20歳で（CD20）Bレベル(Bcell)
ゲームで（ゲムツズマブ）散々（CD33）
もがいて（モガムリズマブ）苦しい（CCR4）

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今日の薬剤📝
💊ポテリジオ(抗CCr4抗体)💊
・ATL細胞表面に存在し白血球遊走に関与する「CCケモカイン受容体4（CCr4）」を標的とし、抗体依存性細胞障害活性により抗腫瘍効果を示すヒト化モノクローナル抗体。
・国内第2...

続きはイシヤクアプリで
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Lichen planus plaque has CCR5 and CCR4 in it.

CCR5 is protective against HIV infection if you’re delta 32.

Research| Döring, van der Vorst, Yan, Neideck et al. present a non-canonical chemokine pathway and demonstrate that CCL17 signals through CCR8, induces CCL3 expression independent of CCR4 and suppresses the functions of atheroprotective Tregs.

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