Pleasure to share our Johns Hopkins Kimmel Cancer Center results from an interception trial studying an off-the-shelf mutant KRAS vaccine in pts at high risk of developing PDAC at #AACR24 #pancsm

Here is a little background on the POLO discussion for the casual browser. #PancSM

POLO is a mockery of science.

First randomized evidence supporting PFS benefit of MDT for OM-pancreatic cancer in P2-EXTEND trial. OS no different, but do other endpoints matter (e.g. maintenance of earlier line systemic therapy)? #GI24 #pancsm

At #AACR23 , our very own Wungki Park, MD, Wungki Park, MD MS of MSKCC Center for Pancreatic Cancer Research is presenting data on molecular profiles and single cell analysis that identified immunogenic pancreatic ductal adenocarcinoma. Check out his poster on Wednesday from 9:00-12:30 in Section 25. #pancsm

Day 2 #GI24 ASCO Highlights #CommunityOncology

1. #IMbrave151

2. GI/ColoRectal Ca in young adults

3. #ALPACA

4. #EXTEND

5. #NETTER2

6. #EMERALD1

#OncEd #MedEd #OncTwitter #MedTwitter #gism #crcsm #pancsm

1/7

Congrats to Adam Wolfe, MD, PhD, Tiantian Cui MD, PhD, and the rest of the stellar team for the Science Advances publication on nutrient scavenging in #pancreaticcancer . 👏
The work uncovers a pivotal role for caveolae-mediated endocytosis (CME) in fueling #PDAC growth. #pancsm #gism

Frequency of Common and Uncommon BRAF Alterations among Colorectal and Non-Colorectal Gastrointestinal Malignancies [May 10, 2024] Dr Amit Mahipal et al. Cancers
mdpi.com/2072-6694/16/1… #PrecisionMedicine #crcsm #esocsm #hpbcsm #pancsm #sbcsm #stcsm

Fantastic morning at #PurpleStride for ⁦PanCAN⁩ with my ⁦IntermountainMedCtr⁩ oncology teammates! We are seeing real progress against the wretched scourge that is pancreatic cancer #pancsm

#LiposomalIrinotecan now FDA Oncology approved for 1L metastatic #PancreaticCancer based off #NAPOLI3 : NALIRIFOX vs. Gem/Abrax

- mOS 11.1mos Vs 9.2mos (HR: 0.83)
- Cross trial comparison, similar OS w/ FOLFIRINIOX
- Save liposomal for later lines?

#gism #pancsm #OncTwitter

Now live at #ASCO23 - Upper GI Poster discussion.

First data of the 3-Arm Arbeitsgemeinschaft Internistische Onkologie - AIO FOOTPATH trial in metastatic #pancsm presented by Ben Westphalen .

In FOOTPATH, sequential application of NAPOLI/FOLFOX was found to be effective and well tolerated.

OncoAlert 🚨

.Marcus S. Noel presenting data on SBP-101 in #pancreaticcancer and his upcoming IIT in the neoadjuvant setting #pancsm #DAVABermudaGI Cure GI Cancers

A special day in NYC supporting PanCAN with survivors, caregivers, doctors & researchers sponsored by NewYork-Presbyterian @weillcornell #endpancreaticcancer #letswintogether #pancsm

Our case of a patient with #pancreaticcancer with MSI & BRAF fusion is now out in JCO Precision Oncology

ascopubs.org/doi/10.1200/PO…

👉BRAF fusion as an alternative route to MSI
👉excellent & long lasting response to #immunotherapy

OncoAlert 🚨 Ben Westphalen #PancSM 💜 #PrecisionMedicine

A great meeting for likeminded people working to improve outcomes of patients w #PancreaticCancer Cutting-edge #CancerResearch MSKCC Center for Pancreatic Cancer Research MSK Department of Medicine The poster room is packed #PancSM #AACRpan23 Eileen M O’Reilly Catherine O’Connor Joshua Schoenfeld Haochen Zhang Katelyn Mullen

Superb graphic 👇 from a JAMA review on pancreatic cancer visualizing the peripancreatic vessels vis a vis operable vs. borderline resectable vs. locally advanced

As a non-surgeon I will be saving this for my discussions with patients #pancsm

pubmed.ncbi.nlm.nih.gov/34547082/

Congratulations to Erik Faber, MD, PhD, former University of Minnesota MD-PhD Program, current The Osler Medical Residency, future GI Oncologist, et al for this tour de force new pub breaking down pancreatic carcinoma TME & IO markers by KRAS expression. Another one from Caris Life Sciences POA GI Group

sciencedirect.com/science/articl… #pancsm

And the fun part is meeting #gurus and #risingstars in #PancreaticCancer world and making new collaborators #CancerResearch The poster room is packed #PancSM #AACRpan23 Talia GOLAN Paulino Tallón de Lara MD, PhD Chisalewine Shivan Sivakumar Eejung Kim

It has been a tough road.
This rainbow brought her luck,
as surgeons were doing their magic.
It bought her some more time.
Some.
Not too much.

How much time before leaving this world is too much?
Never.

#pancreaticcancer #pancsm #oncology #onctwitter #medtwitter #crileymd

New research - Timmer et al - MRI-guided stereotactic ablative body radiotherapy versus CT-guided percutaneous irreversible electroporation for locally advanced pancreatic cancer: the CROSSFIRE phase 2 trial

thelancet.com/journals/langa…

#GITwittter #OncTwitter #PanCSM

The Amer. Radium Society multiD GI expert panel developed these Appropriate Use Criteria evaluating the evidence regarding neoadjuvant tx for pts with #pancreaticCancer , including surgery, systemic tx, & radiotherapy for both oncologic outcomes & QOL. #pancsm
journals.lww.com/amjclinicalonc…