Excited to see Aleksander Szczurek, Emilia Dimitrova, and Jess Kelley 's paper on bioRxiv. Hope you enjoy this deep dive into Polycomb-mediated transcriptional repression using live single-cell imaging approaches! #polycomb
biorxiv.org/content/10.110…

A new study from Maria Bokarewa and Gergely Katona’s labs and our Shuxiang Li on the role of survivin in PRC2 inhibition
cell.com/iscience/fullt…

There are plenty of local favorites that you should be on the lookout for, including crispy hot chicken in da bag, souse, and just about every preparation of conch known to man.

Did you ever wonder how Polycomb represses gene expression?

3/6 This means that Polycomb system does not establish repression through direct control of transcription bursts, but rather acts 'upstream' of this process, effectively creating another layer of regulation

Polycomb protein SCML2 mediates paternal epigenetic inheritance through sperm chromatin academic.oup.com/nar/article/do…

Here's a must-read for anyone thinking about the PRC2 complex in cancer. A common EZH2 antibody may not be what you think.
thanks to Rachel Cherney for this.

journals.biologists.com/bio/article/12…

Very excited to share the work of UNC Genetics PhD graduate student Jeanne-Marie McPherson in her first, first-author paper now available in Genetics Society of America. Fun collaboration with Duronio Lab!
academic.oup.com/genetics/advan…

Now accepted and available as PDF. The work describes a mechanism for altered DNA methylation in cancer:
aacrjournals.org/cancerres/arti…

McPherson, J. E., Grossmann, L. C., Armstrong, R. L., Kwon, E., Salzler, H. R., Matera, A. G., McKay, D. J. and Duronio, R. J. (2023). Reduced histone gene copy number disrupts #Drosophila Polycomb function. bioRxiv. biorxiv.org/content/10.110…

Polycomb sustains promoters in a deep OFF-state by limiting PIC formation to counteract transcription biorxiv.org/cgi/content/sh… #bioRxiv

Learn how Caroline and her husband, Eric, work together to navigate his journey with polycythemia vera (PV).

1/6 I'm pleased to announce new preprint on how Polycomb system controls transcription in living cells
by myself, Rob Klose, Emilia Dimitrova , and Jess Kelley
biorxiv.org/content/10.110…

New insights into gene regulation by Polycomb using live cell imaging. Congrats Aleksander Szczurek & colleagues!

Why do Polycomb targets become CpG-methylated in cancer? See paper by Pfeifer Lab in Cancer Research June 2023

🚘👬 Luana Del Rey SEEEEE COME I BIRILLIIIIII

Super happy to see the latest story from the lab out this morning! Aleksander Szczurek you did an amazing job with this very brave project! Have a look at the manuscript to learn how Polycomb counteracts transcription. Summary by Aleks below

Congratulations Aleksander Szczurek and the rest of the Rob Klose lan! Nice to see this study finally out. Transcription at single molecule level in live cells understanding polycomb!

Mutational Signatures: Reduced histone gene copy number disrupts Drosophila Polycomb function dlvr.it/SqLW2h

Sounds like a must-read for the Polycomb field in general!

There are two other excellent reviews on the emerging topic, which we think are both complementary with ours. I encourage you to check them out as well! From Azusa Inoue | 井上梓 (linked here) and Hendrik Marks (linked in next tweet) (3/5) sciencedirect.com/science/articl…

Filled with non-perishable items, Food Paks are assembled by individuals, families, and churches who partner with Children’s Hunger Fund. CHF then provides the Food Paks to trained partner churches who then share them with hungry families in their communities.

✨Harnessing the power of Drosophila✨ to ask Q's about the roles of canonical and variant histones in genome function and development.
A 🧵about this little journey, which was a pretty wonderful first project in the Duronio Lab and McKay_Lab. 1/9
academic.oup.com/genetics/advan…

2/6 In this work we study how individual molecules of transcripts emerge from Polycomb-target genes in living ES cells to discover that PRC1/H2AK119ub1 represses gene transcription through creating promoter's deep OFF-state refractive
to transcription bursts