Delighted to share our article on the Discovery of SOCS7 as a versatile E3 ligase for protein-based degraders published iScience journal. Thanks to the authors Anaïs Cornebois Marie Sorbara Margot Cristol Pierre Cordelier and our collaborators from Sanofi!
cell.com/iscience/fullt…

Clever approach from the Ciulli lab to do templated library synthesis of homo-degraders of VHL. Would be cool to see this extended to hetero-degraders of other targets.
onlinelibrary.wiley.com/doi/10.1002/an…

Interesting application of the Coferon technology to degraders. Sort of question if any derived efficacy would come from the BRD4 ligand alone. And as usual I’d like to see non-BRD4 examples to bolster the case.
pubs.acs.org/doi/10.1021/ac…

Transforming the Discovery of Targeted Protein Degraders: The Translational Power of Predictive PK/PD Modeling - Haid - Clinical Pharmacology & Therapeutics - Wiley Online Library ascpt.onlinelibrary.wiley.com/doi/10.1002/cp…

There have been a number of CBP/p300 degrader papers of late, and here’s another one.
pubs.acs.org/doi/10.1021/ac…

May is #NCRM24 , a global campaign by AACR to highlight the importance of cancer research. We are progressing a portfolio of next-gen bifunctional protein degraders with the potential to unlock novel treatment options for patients affected by cancer and other severe diseases.

Design of FK866-Based Degraders for Blocking the Nonenzymatic Functions of Nicotinamide Phosphoribosyltransferase | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…

Discovery of CRBN-dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library biorxiv.org/content/10.110…

Development of Novel N-Aryl-2,4-bithiazole-2-amine-Based CYP1B1 Degraders for Reversing Drug Resistance sciencedirect.com/science/articl…

Professor Weiping Tang (Tang Lab, School of Pharmacy, UW-Madison) has earned a new NIH grant to produce novel antibody conjugates for cancer #immunotherapy , also establishing a platform to expedite the development of degraders targeting other #cancer -linked protein targets. bit.ly/4drRZOk

Nice work from Gray and Fischer Lab labs on combinatorial libraries for CRBN molecular glue discovery that yielded a WEE1 degrader. biorxiv.org/content/10.110…

A very interesting pre-print by Jordan Meier and co-authors reports the development of a small-molecule selective degraders of p300 over CBP.
Really impressive work!

Bruton Tyrosine Kinase Degraders in B-Cell Malignancies.
bit.ly/3JS20XF

In Gulu, you are quietly watching as an investor destroys Pece Stream. Moreover, in possession of a forged authorization from your very blunt institution. You are the greatest enabler to environmental degraders in Uganda. Sad that you are prosecuting these helpless & poor ladies.

Today we shared our first quarter financial results & a corporate update. We continued to make strong progress in the first quarter as we executed across our entire portfolio of #PROTAC protein degraders. Read more in our press release. $ARVN #TeamArvinas

これ、おもろそうなTAC。でも低分子でやる必要は(ｷﾘｯ

Small Molecule Lysosome-Targeting Chimeras (SMaLTACs): Receptor Mimetics Targeting Extracellular Proteins for Degradation
Angelo Andres, Senior Scientist, Chemical Biology, AstraZeneca Pharmaceuticals
discoveryontarget.com/protacs-molecu…

Meet the #TETSymp speaker: Cris Mayor-Ruiz (Cris Mayor-Ruiz) IRB Barcelona to give invited talk on targeted protein degradation: chasing molecular glues and coping with resistance to degraders. Register and submit poster abstracts at spkl.io/601842e9C

Discovery of CRBN-dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library biorxiv.org/cgi/content/sh… #biorxiv_molbio

Even when I am out of enforcement, staff still use my name to raise the bargain and extort huge sums of money from degraders. I know them and will expose them here on a good day, including evidence of transactions ...