#HappyBirthday to the #GreenwichVillageHistoricDistrict , landmarked #OTD in 1969. Celebrate all things GVHD today with our map + tours, incl. then + now photos of nearly 3,000 bldgs and more than 1,000 points of historic interest on dozens of tours: gvshp.maps.arcgis.com/apps/Shortlist…

今日の通院。肝臓の数値は高いまま。

　相変わらず少し動くだけで息苦しくなる、

　ステロイドがここ1ヶ月で20mgから10mgに減ったのでそのせいかと聞いてみたけど、直接的には関係ないそう。でも減らした事でGVHDが起きてるかも知れないから来週今度はCTを取ることに。原因だけでもわかってくれ😭

📋 Chronic GVHD has “extraordinary” social-emotional impacts on school experiences for children and young adults, according to a recent study by a team from Cincinnati Children's.

➡️ Learn more: buff.ly/3U8WhRJ

#bmtsm #GVHD

The 'all-in-one' approach 😳

Sequential CD-7 CAR and haploidentical HSCT without conditioning or GVHD prophylaxis 😲😳

Previous lines of Rx: 9.5 😳

N=10
1 death
3 GVHD
2 relapse
At 15 months, 6 are in MRD negative CR 🙌🏼

Incredible study 💪🏻

nejm.org/doi/full/10.10…

ความเหงาแบบไม่มีที่

Presented my first ever Grand Rounds today for the Hematology Department! WashU Heme/Onc Fellowship Title: “A Rare and Deadly Review on Transfusion Associated GvHD”

Of 10 patients with relapsed or refractory hematologic cancers who received sequential CAR T-cell infusion followed by allogeneic stem-cell transplantation without GVHD prophylaxis, 6 were alive and disease-free at last follow-up. Read the full article: nej.md/4dqsTQ3

Original Article: Sequential CD7 CAR T-Cell Therapy and Allogeneic HSCT without GVHD Prophylaxis nej.md/4dqsTQ3

Editorial: CAR as Booster to Launch Allogeneic Transplantation in Refractory Leukemia nej.md/3Wb0R4z

#Oncology

CB-010, allogeneic CD19-directed CAR-T

Single dose in Non-Hodgkin lymphoma patients:

* Well tolerated. No GvHD occurred
* 94% ORR, 69% CR rate, and 44% CR ; ≥6 months
* Durable CRs
* PR to CR conversions observed in 3 patients

investor.cariboubio.com/static-files/7…

After initial clinical response, flares of acute GVHD are common and associated with higher NRM. ow.ly/Az2Q50Rmrym #transplantation

CD7 #CARTCell Therapy as a preconditionning for Allogeneic HSCT without GVHD Prophylaxis.
nejm.org/doi/full/10.10…

Steroid tapering after GVHD Rx: not too fast, not too slow
ow.ly/nUUb50Rmrgt #InsideBloodAdvances #IBAs #transplantation

Interesting paper from the SAAWP of The EBMT in Blood Journal looking at MUD v MMUD and Haplo #HCT for #SAA . Superior OS and less GVHD seen with MUD versus both alternative donors. Austin Kulasekararaj AA&MDSIF sciencedirect.com/science/articl…

Javier Bolaños Meade, MD In essentially EVERY trial that has randomized Auto to no Auto following intensive induction therapy for MM, AutoSCT has been associated with prolonged PFS. If the Myeloma docs are not willing to accept PFS as a valid endpoint in BMT trials, they shouldn't in CAR-T studies

Episode 3 of Patient Advocacy Voices is here. Listen in as Meredith Cowden from Cowden Foundation discusses #GVHD and the power of forging alliances and collaboration between patients and organizations to meet common goals with hosts Eric Racine and Angie Bricco. spkl.io/601542vPZ

GM-CSF plays a major role in the development of acute gastrointestinal #GVHD . This review summarize the potential role of GM-CSF in the GVT effect, discussing some potential strategies for exploiting GM-CSF in the context of #alloHCT . Read more: ow.ly/co2I50Rk9PQ

Lee-Kai Sun presenting at the 2024 i4Kids Symposium! His presentation 'Deletion of AMPK reduces glycolytic compensation and disease potential of GVHD-causing T-cells' showcases work aimed at making allogeneic transplants safer through metabolic manipulation of immune cells. #GVHD

Amazing that #PTCy makes Apple News! We can’t overstate the advancement.

We can still do better, though!

Preventing GVHD and relapse — with the same drugs?! We are trying to accomplish this.

👍💪

Autologous transplant has been in the ICU for a while... thelancet.com/journals/lanha…