Several cytokines can repress FLG through JAK1/STAT3 signaling in keratinocytes. We found high levels of IL-6, IL-13, IL-22 and OSM secreted by malignant T cells. Blocking these completely counteracted the effect of malignant T cells on FLG expression in keratinocytes.

Brian Hackel 💉❤️ ✊🏻🏳️‍🌈 JAMA I think it has a ton to do with keratinocytes alpha 2 agonism

Handelin protects human skin keratinocytes against ultraviolet B-induced photodamage via autophagy activation by regulating the AMPK-mTOR signaling pathway

sciencedirect.com/science/articl…

Cindy Lu Jette is Mataray 😊 Thank you. Yeah that's what I thought, we know it's an auto immune process. It's a viral induced autoimmune disease.

Was reading about psoriasis yesterday. The keratinocytes make chemicals that keep the T cells attacking them. Like a hellish feedback loop.

Effect of zinc ions on the proliferation and differentiation of keratinocytes #preprints researchsquare.com/article/rs-291…

Mechanisms of Sodium-glucose Cotransporter 2 Inhibitors in Heart Failure #Heart_failure doi.org/10.15212/CVIA.…

Malignant (cancer) T cells in CTCL express high levels of the TOX protein. Association of defective skin barrier and TOX+ cells close to epidermis suggest that the defect may be caused by the proximity of malignant T cells and epidermal keratinocytes.

… Supplementation of nicotinic acid and its derivatives up-regulates cellular NAD+ level rather than nicotinamide derivatives in cultured normal human epidermal keratinocytes

researchsquare.com/article/rs-248…

Zachary Smith Ok, Keratinocytes are the predominant cell type of epidermis and originate in the basal layer, produce keratin, and are responsible for the formation of the epidermal water barrier by making and secreting lipids.

Effects of 5G-modulated 3.5 GHz radiofrequency field exposures on HSF1, RAS, ERK, and PML activation in live fibroblasts and keratinocytes cells #sarcoma dlvr.it/SpWngg

Dr. Lisa Iannattone T. Ryan Gregory Yes, if it were vindictive bureaucrats it would be unsurprising. But good gravy! They sure aren't like the authors of the paper I read the abstract of about the interaction between T cells and keratinocytes in psoriasis. Fucking amazing! So complicated. #TumorNecrosisFactor

🔬 Two-photon excitation and CARS microscopy for structural and molecular assessment of lesions in multiple sclerosis 🔬

💡 What are your in vivo imaging challenges? bliqphotonics.com/solutions/mult…

#microscopy #twophoton #multiphoton #invivo

JAK/STAT3 signaling plays a key role in repression of FLG in inflammatory skin disorders but little is known about STAT3 activity CTCL skin. We found strong STAT3 activation in T cells and keratinocytes in lesional, but not in non-lesional, skin of CTCL patients.

Alex Chan led our #JournalClub this month. He & Dr Maddie White chose, “Rapid culture of human keratinocytes in an autologous, feeder-free system with a novel growth medium,” written by Feisst et al. University of Auckland | Waipapa Taumata Rau and published by Cytotherapy Journal (@ISCTglobal).

#novelmethod

Tetrapeptide-61 is a peptide which delivers improve skin vitality and yields a younger skin appearance. This works especially on aged fibroblasts and keratinocytes to allow them to regain their youthful energy and promote anti-aging appearances.

Chengdu Youngshe Chemical Co.,Ltd

My Four Moods.
miahcombat.com/collection/my-…
#cats

Indeed, culture of keratinocytes in the presence of malignant T cells (unlike non-malignant T cells) is sufficient to reduce the expression of barrier proteins (FLG & FLG-2). This reduction is caused by soluble mediators and associated with STAT3 activation in keratinocytes.

Immature mandarin orange extract increases the amount of Hyaluronic acid in human skin fibroblast and keratinocytes #preprints researchsquare.com/article/rs-281…

TLDR: Cytokine-producing malignant T cells markedly reduce barrier protein expression in keratinocytes through JAK/STAT3 signaling. Barrier protein is restored by JAK-inhibitors indicating them as a novel treatment option in CTCL patients

Highlights below
doi.org/10.1182/blood.…

Roger Seheult, MD Which natural way - pineal gland, cherries, enterochromaffin cells, grapes, keratinocytes, strawberries, NK cells….

This indicates the skin barrier of CTCL patients may be improved by JAK inhibitor treatment. Indeed, treating keratinocytes, reconstructed epidermis and lesional CTCL skin biopsy explants with a clinical JAK-inhibitor (Tofacitinib), all improved FLG expression levels to normal.

财富 One would argue that what you refer to as dirt are actually keratinocytes that contains the melanin pigment 💁🏽‍♂️

Someone should do research on insulin as treatment for Xylazine wound treatment. Would migrate keratinocytes that I theorize are stagnated due to Alpha-2 agonism signal. (he says, into the universe hoping someone smarter will hear)