#IQFSeminar #IQFSeminar io
Hormone-mediated disassembly and inactivation of a plant E3 ubiquitin ligase complex

🗣️Vicente Rubio, @cnb_csic
🗓️Wednesday 17/04, 12:00 h
📍 #iqf

🚨PAPER ALERT!🚨

Excited to see our collaborative paper on a new SUMO-targeted Ubiquitin ligase in stress management is finally online at NSMB!

Thanks Niels Mailand Julio L Thijn Brummelkamp for the collaboration!

nature.com/articles/s4159…

Discovering a new pathway to fight obesity! 🧬 UCF's latest patent apl., #US20240117357A1 , reveals how MUL1 E3 ubiquitin ligase controls fat metabolism & resists #Obesity in high-fat diets. Potential treatments for obesity & related diseases on the horizon! #HealthTech #medicine

Extended reading from Steve Jackson Lab Julian Stingele & Lab: biorxiv.org/content/10.110…

Tomorrow EpiSeedLink coordinator, Vicente Rubio will give an interesting talk at the IQF-CSIC at 12:00. It is about Hormone-mediated disassembly and inactivation of a plant E3 ubiquitin ligase complex. Are you going to miss it?🪴🧬😀

Science is publishing an Erratum for the October 2001 Report 'Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase.'

Learn more: scim.ag/6EG

🐱(姿势有参考)

My 2nd project is out in NatureStructMolBiol ! Following up the SUMO-RNF4 paper, from studying the replication-independent DPC repair, we identified TOPORS as a novel SUMO-targeted ubiquitin ligase, with SUMO1-binding preference. Thanks all in Niels Mailand Lab
nature.com/articles/s4159…

お、こっから先はligase以外全部江か
いや壮観やなｗｗ

Can we conjugate ubiquitin in a non-canonical fashion? Join Breanna Zerfas and me for two compelling seminars at 11 am EDT, 8 am PT, 4 pm BST, 5 pm CEST: Jonathan Ostrem: “Direct Small Molecule Ubiquitination”
Darci Trader: “Bypassing an E3 Ligase for TPD'

Check out the paper here:
nature.com/articles/s4159…

For support of Alexandra Henrion-Caude's claims in 'The Sorcerer's Apprentices,' see: 'Development of Allosteric Ribozymes for ATP and l-Histidine Based on the R3C Ligase Ribozyme' mdpi.com/2075-1729/14/4… 4/17/24
If the bioweapons cartel cannot prevent you from learning how ATP-dependent

SARSCoV2 spike S2 subunit inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells; interaction between SARS-CoV-2 spike, p53 and MDM2 (E3 ligase, which mediates p53 degradation) in cancer cells: immunoprecipitation. biorxiv.org/content/10.110…

New Paper from I04-1 in NatureStructMolBiol doi.org/10.1038/s41594… (pdbe.org/8BTL)

Finally, through fractionation experiments, we show that Btn2-SUMO opposes K48-Ubiquitin chain buildup in the MMS-induced insoluble proteome when Apj1 is absent. Additionally, we highlight the Slx5/8 complex as the primary E3 ligase for the Apj1-degradation pathway! (8/10)

New webinar is upcoming!

Join us on May 15th to hear Dr. Sonja Lorenz talk about her work on regulation and specificity of the HACE1 ubiquitin ligase – and how #MassPhotometry provided key information on its oligomerization behavior.

Register here! 👇
events.bizzabo.com/592178

Design of a recombinant asparaginyl ligase for site-specific modification using efficient recognition and nucleophile motifs

nature.com/articles/s4200…

Design of a recombinant asparaginyl ligase for site-specific modification using efficient recognition and nucleophile motifs nature.com/articles/s4200…

Terry Hébert Cool work Terry! Might even pass the Alberta government's research ideology screening test based on the swastika-like appearance of the ligase.

As I traverse the pathways of life, may the kinase of ambition phosphorylate my dreams, and the ligase of friendship bond me with those who cherish me.