Our new study shows mitochondrial amino acid fermentation as the missing link in sustaining cancer cell energy metabolism and viability in hypoxia. (doi.org/10.1101/2024.0…).

Is today’s resistance by the cancer establishment to the mitochondrial metabolic theory like the resistance of the Catholic Church to the heliocentric theory of the solar system? Look carefully at the Graphical Abstract in our article (doi.org/10.3390/metabo…).

Glutamine driven mitochondrial substrate level phosphorylation: A major source of ATP synthesis in anoxic cancer cells. A fact that should be recognized and understood.
(doi.org/10.1038/s41598…).

Pablo Kelly begins his 10th year of survival with terminal stage 4 brain cancer without ever receiving radiation or chemotherapy (doi: 10.3389/fnut.2021.682243). Please visit his website for information on his non-toxic metabolic therapy (pablosbrainjourney.com).

The Glucose-driven glycolysis pathway fuels the fermentation engine of cancer cells!
doi.org/10.1016/j.isci…)

High grade gliomas (HGG) are the leading cause of cancer death in children. Our latest preclinical study shows how the ketogenic diet can enhance therapeutic action while reducing toxicity of cancer drugs used for managing pediatric HGG.(doi.org/10.1101/2023.0…)

Complete resolution of malignant mast cell tumor in a dog using ketogenic metabolic therapy alone. Might this strategy also work for other cancers in dogs and humans?
frontiersin.org/articles/10.33…

Our new study shows that OxPhos is not needed for the viability of cultured breast and liver tumor cells making oxygen consumption an ambiguous marker for ATP synthesis through OxPhos (doi: doi.org/10.1101/2022.1…).

The Glucose Ketone Index predicts overall survival and metastasis of mouse tumor cells to visceral organs and brain lcm.amegroups.com/article/view/8…

Extraordinary radiographic and clinical responses were recently documented for several malignant brain cancer patients that were treated with non-toxic ketogenic metabolic therapy at the Barrow Neurological Institute, Phoenix, AZ (DOI: 10.7759/cureus.26457)

Our new study shows that glutamine-driven ATP synthesis through mitochondrial substrate level phosphorylation can compensate for OxPhos loss under hypoxia. Tumor cells can also use this mechanism to remain viable under limited oxygen. (doi.org/10.1101/2022.0…).

Glucose and glutamine drive the rapid growth of GBM, a deadly brain cancer. Radiotherapy increases glucose and glutamine in the GBM microenvironment. Do the GBM survival data in Figure 1 of our attached paper fit Einstein’s definition of insanity? (10.3389/fonc.2022.968351).

A few free tickets are still available for the ketogenic therapy symposium in NYC. Please consider attending if interested in non-toxic cancer therapy. x.com/tommydeemd/sta…

Our new paper describes therapeutic strategies for the non-toxic metabolic management of Glioblastoma and other cancers (DOI 10.3389/fonc.2022.968351).

Check out our new paper with Dr. A. Evangeliou on the long-term therapeutic effects of the restricted ketogenic diet on a patient with primary lung cancer and brain metastasis. DOI: 10.7759/cureus.27603.

A major new study has identified for the first time unique protein signatures linked to inflammation and energy metabolism in Alzheimer's disease. (doi.org/10.1038/s41593…)

Cancer Commons cancercommons.org/latest-insight…

Glucose and glutamine drive glioblastoma (GBM), a deadly type of brain cancer. Radiation increases glucose and glutamine in the microenvironment. Should radiation therapy be justified for GBM in light of this? (doi: 10.3389/fnut.2021.682243; DOI 10.1007/s11064-019-02795-4)

It is impossible to believe simultaneously in two opposing theories explaining the same set of phenomena (Ernst Mayer) (doi.org/10.3390/metabo…).

Another new study showing that cancer is a mitochondrial metabolic disease driven primarily by the fermentation of glucose and the amino acid glutamine (doi.org/10.1016/j.molm…).