Venk Murthy MD PhD(@venkmurthy) 's Twitter Profileg
Venk Murthy MD PhD

@venkmurthy

#cardiometabolic #prevention; Multimodality #cvimaging; Posts may be my opinions & are not medical advice; RT≠endorse

ID:25029854

linkhttps://scholar.google.com/citations?user=nNET6osAAAAJ calendar_today18-03-2009 04:47:46

56,8K Tweets

22,0K Followers

1,9K Following

Follow People
Venk Murthy MD PhD(@venkmurthy) 's Twitter Profile Photo

The Apple Watch Afib algorithm is calibrated to reduce false positives at expense of increased false negatives

If the same is done for a cuffless BP algorithm, it could cause great harm by falsely reassuring people

account_circle
Benoy Shah MD(@dr_benoy_n_shah) 's Twitter Profile Photo

As we approach the end of 2023, what was the most important paper you read this year?

Mine wasn't in cardiology

I think this went under the radar a little, but it shouldn't have...the impact of private equity (PE) takeovers in healthcare

An end-of-year 🧵

As we approach the end of 2023, what was the most important paper you read this year? Mine wasn't in cardiology I think this went under the radar a little, but it shouldn't have...the impact of private equity (PE) takeovers in healthcare An end-of-year 🧵
account_circle
Benjamin Ryan(@benryanwriter) 's Twitter Profile Photo

'In a recent paper published in The Proceedings of the National Academy of Sciences, Clark and 38 co-authors argue that, in science, censorship often flows from within, as scientists choose to avoid certain areas of research, or to avoid publishing controversial results.'…

'In a recent paper published in The Proceedings of the National Academy of Sciences, Clark and 38 co-authors argue that, in science, censorship often flows from within, as scientists choose to avoid certain areas of research, or to avoid publishing controversial results.'…
account_circle
Venk Murthy MD PhD(@venkmurthy) 's Twitter Profile Photo

Excellent article!

Treatments for sickle cell are urgently needed for this horrible disease. Gene therapy makes sense but many/most sickle cell patients won't get that - pill would change the game.

In that context, why are we pursuing PCSK9 gene tx when we have plenty of drugs…

account_circle
Venk Murthy MD PhD(@venkmurthy) 's Twitter Profile Photo

This makes no sense! Plenty of non-gene tx drugs for obesity available and in pipeline. No rush for this niche.

Fails the test of 'should we' for gene tx I discuss here:

venkmurthy.substack.com/p/editing-the-…

account_circle
Venk Murthy MD PhD(@venkmurthy) 's Twitter Profile Photo

Interesting development. AUCs have many problems

* Weak evidence basis
* Many conflicting ratings
* Difficult to consistently apply

AUC = Appropriate Use Criteria

account_circle
Jay Bradner, M.D.(@jaybradner) 's Twitter Profile Photo

Important from Recursion on genomic bias of CRISPR screening. Is the observed loss of chromosomal arms revealed problematic for Cas9 therapeutics? Much attention to indels and off targets by seq in tox, but how to assure integrity of chromosome arms in patients?

account_circle
Florian Zores(@FZores) 's Twitter Profile Photo

look at this 20 years old RCT comparing cardiac rehab and PCI in CCD

'in patients with CCD and angiographically documented stenosis, a 12-month exercise training program resulted in a higher event-free survival rate than with PCI intervention'

ahajournals.org/doi/full/10.11…

account_circle
Venk Murthy MD PhD(@venkmurthy) 's Twitter Profile Photo

Genetics community:
Awesome paper on PRS in journal with massive impact factor! (which doesnt adjust or test incremental value beyond standard risk scores)

Also genetics community:
No serious person should consider PRS as a standalone without considering other risk factors

account_circle
Venk Murthy MD PhD(@venkmurthy) 's Twitter Profile Photo

PRS was hyped precisely as a stand alone screening test!

When Cecile Janssens Frank Harrell & I pointed out that CAD PRS was at best moderate effect size, people attacked us personally & suggested we had ill motivations, were luddites, or fools

Few in the genetics community pulled…

account_circle