The bleeding ❤️plant is one of my favorites ⁦Dena van den Bergh⁩ ⁦Judy Stone⁩ ⁦Adrian Brink⁩

IDSA guidelines for diagnosis and management of CRBSI and IDSA guidelines for evaluation of fever in critically ill patients both recommend drawing blood cultures from a central venous catheter (CVC) and percutaneously if the catheter is a suspected source of infection #IDXposts

🆕️🔥Systematic Review & Meta-analysis
6 retros N:1746
Short Vs. Prolonged Duration of Therapy for Pseudomonas aeruginosa Bacteremia
No sig # in 30d mortality
Ongoing RCTs 7d Vs 14d:
SHORTEN-2
OPTIMISE
BALANCE
H/t SHORTEN-2 trial #IDXposts Brad Spellberg
journalofhospitalinfection.com/article/S0195-…

This multicentre prospective cohort study by Aisling Rafferty et al. examined antimicrobial prescribing in patients discharged from emergency departments across Ireland and identified areas for #AntimicrobialStewardship
doi.org/10.1093/jacamr…
OUP Medicine Oxford Journals #JACAMRNews

🆕️🔥 in #IJAA
Treatment of infections caused by multidrug-resistant Gram-negative
bacilli: a practical approach by the Italian (SIMIT) and French (SPILF) Societies of Infectious Diseases #IDXposts
Cc #ESCMIDGLOBAL2024 folks ICYMI
Thanks Ignacio uman sciencedirect.com/science/articl…

🔥GAME CHANGER RCT🔥
Multicenter open label
Cefiderocol was non inferior and not superior to SOC antibiotics in patients with Healthcare Associated and Hospital-Acquired GN bacterial BSI
Slides shared by Sean Ong
#ESCMIDGlobal2024
A game-changing trial? #IDXposts

And the winner is..... #ESCMIDGlobal

Rapid diagnostic tests and antimicrobial stewardship programs: What is their relative contribution to improving clinical outcomes in BSI? Great work by Anna Maria Peri Patrick Harris academic.oup.com/cid/article/do…

Super interesting !
🆕️⚡️⚡️ Journal of Infectious Diseases
Serum Gasdermin D (GSDMD) for Early Diagnosis of Bloodstream Infection and Differentiating Bacterial from Fungal Infections #IDXposts academic.oup.com/jid/article-ab…

K. pneumoniae is capable of resistance to β-lactam antibiotics through expression of β-lactamases and downregulation of outer membrane porins
🆕️🔥Excellent article
What Contributes to the MIC? Beyond β-Lactamase Gene Detection in Klebsiella pneumoniae academic.oup.com/jid/article/do…

#ECCMID24 Judith Breuer: Interesting slide of comparative sensitivity of untargeted nanopore, Illumina and Twist enrichment panel for detection of viral DNA/RNA in spiked samples

#ECCMID2024 impressive 7 year record from Charles Chiu at USCF of CSF metagenomics for diagnosis of meningo-encephalitis

Veterinary antibiotic prescribing practices are influenced by seniors, shared through peer networks and shaped by corporate groups:
doi.org/10.1093/jacamr…
OUP Medicine Oxford Journals #JACAMRNews

🆕️🔥Combination of anti-staphylococcal β lactam with standard therapy compared to standard therapy alone for the treatment of MRSA bacteraemia: a post hoc analysis of the CAMERA2 trial using a desirability of outcome ranking (DOOR) approach Steven Tong academic.oup.com/ofid/article/d…

Vasilakopoulou et al. report that the novel rapid NG-Test DetecTooL OXA-23 assay was fully sensitive & specific for detection of OXA-23 carbapenemase directly from clinical blood cultures positive for A. baumannii:
doi.org/10.1093/jacamr…
OUP Medicine Oxford Journals #JACAMRNews

In vitro-in vivo discordance in β-lactams activities against MBL producing Enterobacterales has been described
🔥Deciphering the Efficacy of β-Lactams in the Face of MBL Derived Resistance in Enterobacterales
Supraphysiologic Zinc in Broth is the Culprit🔥 academic.oup.com/ofid/article/d…

Eger et al. found not only MDR Enterobacterales but also 2 isolates resistant to cefiderocol in Ghana surface water samples in, also indicating potential for transmission to humans and animals:
doi.org/10.1093/jacamr…
Schaufler Lab OUP Medicine Oxford Journals #JACAMRNews

High-risk E coli clones causing neonatal meningitis and association with recrudescent infection : doi.org/10.7554/eLife.…

imb.uq.edu.au/article/2024/0…

UQ Medicine UQ Science Schembri Lab Brian Forde

Yamba et al. highlight the need to use local susceptibility data to create country-specific treatment guidelines in line with WHO AWaRe and enforce regulations that prohibit easy access to antibiotics:
doi.org/10.1093/jacamr…
kaunda OUP Medicine Oxford Journals #JACAMRNews

What are the diagnostic stewardship strategies for urinary tract infections? Here's a great visual.
journals.asm.org/doi/full/10.11…
Sharon Onguti Barbara Trautner
#sheaspring2024