Very happy to finally finish this paper and the corresponding code and tutorial. Grateful to all those who helped make this happen. Hopefully it will contribute to making #cryoET more accessible. #teamtomo

biorxiv.org/content/10.110…

We are excited to relaunch the Midlands Biophysical Network. Sign up via the link below University of Leicester Uni of Birmingham University of Warwick Uni of Nottingham #WeAreUoN LISCB Midlands Innovation

#Endometriosis takes 7-10 years to diagnose, on average; but a surge in research is finally leading to new diagnostics and treatments. News feature from Clare Watson #InternationalWomensDay2024
nature.com/articles/s4159…

I don't want to beat our own drum here, but I just wanted to say that #ModelAngelo by Kiarash Jamali is a fantastic program that has yet again completely blown me away today. 🥳

Our article elucidating the structural role of Lig4 in DNA end synapsis during NHEJ is now out at Nat Comms link.springer.com/10.1038/s41467…

Our new collaborative manuscript with Sébastien Britton and Calsou lab identifying a structural role for DNA-PKcs in regulating Ku stiochiometry during DSB repair.
biorxiv.org/content/10.110…

Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction by Amanda Chaplin in Nucleic Acids Res pubmed.ncbi.nlm.nih.gov/37870477/

POLQ and Pol Delta are working together to synthesize DNA during DSB repair via MMEJ. 👏👏👏
Also explains how POLQ seals post-replicative ssDNA gaps on the lagging strand during replication, which I and others have previously observed. nature.com/articles/s4158…

Our paper is out, Bravo and thanks to all the contributors!!👏👏
Take home: after DSB induction, gH2AX domains self-segregate to form a new chromatin compartment, in which some DDR genes also physically relocate to potentiate their expression.
rdcu.be/doT6W

Head over to our blog to read about last month's 2023 Lister Institute Annual Meeting, where our community gathered for an inspiring two days of talks at Corpus Christi, Oxford. #ListerFellows #science lister-institute.org.uk/lister-annual-…

My new review on the mechanism of NHEJ is out in DNA Repair. It provides the emerging view of how DNA end synapsis and processing are coordinated. authors.elsevier.com/sd/article/S15…

[🗓️ #event ] 🧬Interested by #NHEJ pathway and its roles in development and #cancer ?
It's still time to register for the three day international meeting that will be held in Fontenay-aux-Roses (France 🇫🇷) on September 27-29, 2023.
All informations online➡️nhej2023.sciencesconf.org

Happy to share the latest work by Amanda Chaplin in collaboration with Kathy Meek, Charbonnier Lab, ourselves Cambridge Biochemistry and others
cell.com/structure/full…

So nice collaboration with Amanda Chaplin, Patrick Calsou and Sébastien Britton. Congrats to He's lab in back to back

Great structures of Ku-PAXX made by Muriel from Charbonnier Lab lab and collaborators from Amanda Chaplin lab published in Science Advances doi.org/10.1126/sciadv…. Congratulations 🎉!

Amanda Chaplin Cambridge Biochemistry LISCB Charbonnier Lab Also check out the related research article from The He Lab science.org/doi/10.1126/sc…

Amanda Chaplin Cambridge Biochemistry LISCB This was part of a highly collaborative project including ourselves at BiocEM Cambridge, Charbonnier Lab , Kathy Meek, Patrick Calsou and others

The latest work from Amanda Chaplin, work initiated at Cambridge Biochemistry and continued at LISCB science.org/doi/10.1126/sc…

Lovely to see this BBC News (UK) piece about Amanda Chaplin - one of our newest cohort of #ListerFellows ! bbc.co.uk/news/uk-englan…

phys.org/news/2023-03-d…