That's a wrap for the #MedChemFrontiers24 EFMC ACS Division of Medicinal Chemistry! See you in Spring 2025 for #MedChemFrontiers25 in CHICAGO, hosted by Terry Moore 🏳️‍🌈!

#medchem #chembio #drugdiscovery

Congratulations to all five Chemistry Europe & @Acsmedi poster prize winners at #MedChemFrontiers24 ! Ahmed Amin @HIPS, Angsar Oberheide TU Eindhoven, Jerrett Holdaway University of Minnesota Medicinal Chemistry, Marin a Westerveld Utrecht University & Maxime van den Oetelaar TU Eindhoven!

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Check out our paper published in ChemMedChem.

Inspiring talk by George Vandeveer from Biogen at #MedChemFrontiers24 . He talked about their work on the covalent, brain-penetrant BTK inhibitor BIIB-129 based on (substituted) acrylamides for applications in multiple sclerosis.

Thanks to EFMC & ACS Division of Medicinal Chemistry for the Chemistry Europe lecture by Maria João Matos at #MedChemFrontiers24 !

We invite everyone to follow, read & publish in ChemBioChem & ChemMedChem, YOUR official EFMC journals!

Looking forward to the EFMC-ISMC in Rome in Sept. #medchem #chembio

Interesting talk by Maria Joao Matos Maria João Matos at #MedChemFrontiers24 . She talked about her group's amazing research on hybrid compounds for neurodegenerative diseases. …mistry-europe.onlinelibrary.wiley.com/doi/abs/10.100…

An interesting talk about the neurodegenerative disease projects of Maria João Matos. Thank you for being our Chemistry Europe representative at #MedChemFrontiers24 EFMC ACS Division of Medicinal Chemistry EFMC Young Scientists Network!
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Follow, read & publish in ChemBioChem & ChemMedChem, your official EFMC journals!

Interesting talk by Rachel Lagiakos H. Rachel Lagiakos of Schrödinger at #MedChemFrontiers24 . She talked about the many ways, in which computational methods can support drug discovery on the example of KAI-11101, a brain penetrant DLK inhibitor for neurodegenerative diseases.

Check out recent articles & front covers from the #MedChemFrontiers24 Chemistry Europe Lecturer Maria João Matos:

…mistry-europe.onlinelibrary.wiley.com/doi/10.1002/cm…

…mistry-europe.onlinelibrary.wiley.com/doi/10.1002/cm…

…mistry-europe.onlinelibrary.wiley.com/doi/10.1002/cm…

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ChemMedChem & ChemBioChem are official journals of EFMC

Our esteemed Chemistry Europe lecturer at #MedChemFrontiers24 is board member Maria João Matos (@cimususc), discussing 'Hybrid Compounds for Neurodegenerative Diseases: from Small Molecules to Targeted Therapies'.

Learn more at mariacmatos.wixsite.com/website.

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Down to the final session at #MedChemFrontiers24 EFMC ACS Division of Medicinal Chemistry with five talks on recent advances in neurodegenerative diseases.

#medchem #chembio #pharma #drugdiscovery #neuromedicine

Last talk of the morning session at #MedChemFrontiers24 is given by Rita Di Martino (Rita Maria Concetta Di Martino) on “Leveraging New Chemical Modalities for Reprogramming IDO1 Half-Life in Cancer Immunotherapy”
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After the coffee break, the #MedChemFrontiers24 programme starts again with the session on “Targeting Immune Checkpoints with Small Molecules”, chaired by Eddy Sotelo (Eddy Sotelo).
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SEQT

Interesting talk by Stefan Schiesser AstraZeneca at #MedChemFrontiers24 . He talked about the importance of new synthetic methods for drug discovery. Interesting insights into late-stage functionalization of phenols and into the synthesis of N-CF3 amines. …mistry-europe.onlinelibrary.wiley.com/doi/full/10.10…

Last early-career investigator on the stage for this session at #MedChemFrontiers24 is Olha Kolodiazhna, presenting Enamine Ltd 🇺🇦 latest achievements in the preparation of borylated cyclobutanes via thermal [2+2]-cycloaddition.
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And I like to mention that Stephen Fesik is also the first chemist featured in Darryl B McConnell’s #RASHallOfFame .

Introduced by Gregg Siegal, the ending PL of today’s programme at #MedChemFrontiers24 is given by Stephen Fesik (Vanderbilt University), talking of cancer Drug Discovery using Fragment-Based methods.
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Before Stephen Fesik VU Chemical Biology begins his FBDD talk, he shares personal lessons: 1)Follow your dreams. 2)Don't listen to those who say it can't be done. 3)Develop a plan & execute. 4)Try VERY hard. 5)Pay attn to the unexpected.
#MedChemFrontiers24 EFMC ACS Division of Medicinal Chemistry

A packed room at #MedChemFrontiers24 for the talk of Stephen Fesik (VU Chemical Biology Vanderbilt-Ingram Cancer Center Vanderbilt Center for Structural Biology)-- Father of Fragment-Based Drug Discovery. Now discussing FBDD for cancer therapeutics.

lab.vanderbilt.edu/fesik-lab

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Next talk of the session at #MedChemFrontiers24 comes from Stanford University, with Franco Faucher (@mbogyo lab) talking about selective substrate identification using chemically modified phage display.
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