#Multimorbidity is commonly defined as the co-occurrence of at least two chronic disorders in the same individual - mechanisms of its development include social and biological factors, and prescribed medications.

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Severe cutaneous adverse reactions have a number of different clinical presentations including blisters on macules, extensive epidermal detachment, atypical targets with central blistering and areas of erythema studded with numerous minute pustules.

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The prevalence of HLA risk alleles varies significantly by region, with high prevalence rates in South and Southeast Asia.
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There are four proposed models for initiating T-cell recognition and activation in severe cutaneous adverse reactions:
The “hapten/prohapten” theory, the “p-i” concept, the “altered peptide repertoire” model and “T-cell overactivation”.

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Most signs and symptoms of #hypothyroidism are non-specific and affect multiple organs and tissues.

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The simultaneous activation of cytotoxic granule-mediated programmed cell death, apoptosis, and necroptosis cause widespread keratinocyte death in Stevens–Johnson syndrome and toxic epidermal necrolysis.
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The mechanisms involved in Stevens–Johnson syndrome and toxic epidermal necrolysis result in keratinocyte death, skin damage, and blistering.

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#Malaria can be effectively prevented: vector control approaches (insecticides and physical barriers, such as bed nets) and chemoprevention (mass administration of antimalarial drugs) can reduce disease burden.

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#WorldMalariaDay

Get Primed on Severe cutaneous adverse reactions with our NEW PrimeView!

FREE to download this week!

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Our NEW Primer on Severe cutaneous adverse reactions is live today!
By Hung, Mockenhaupt, Kimberly Blumenthal, MD, MSc, Abe, Ueta, Ingen-Housz-Oro, Phillips & Chung.

Check it out here: go.nature.com/3UxTT8C

#PCOS is characterized by elevated androgens, irregular menstruation and polycystic ovaries go.nature.com/49I6J8A

Multiple pattern recognition receptors are involved in recognition and immune response modulation, each responsible for a Candida molecule. go.nature.com/494K3Pq

Adipocyte hypertrophy and decreased production and secretion of #adiponectin are strong drivers of insulin resistance in #PCOS , independent of obesity go.nature.com/3w0S7U7

#Hyperandrogenism and hyperinsulinaemia are two key features of #PCOS , driving #insulin resistance in the adipose tissue, skeletal muscle and liver go.nature.com/3w0S7U7

Cardiac tamponade is a potentially life-threatening emergency involving compression of the heart caused by accumulation of fluid in the pericardial sac. go.nature.com/3DnyCoG

In women with #PCOS and irregular cycles, the endometrium is exposed to #oestrogen without counteracting #progesterone action go.nature.com/3w0S7U7

#Intracerebral #haemorrhage occurs when blood enters the brain parenchyma following the bursting of a cerebral blood vessel go.nature.com/3mN8UVC

In women with #PCOS , the #gonadotropin -releasing hormone pulse frequency is elevated, increasing the luteinizing hormone frequency, whereas follicle-stimulating hormone is unchanged or slightly reduced go.nature.com/3w0S7U7

The inheritance of #PCOS likely involves genetic, environmental and epigenetic factors go.nature.com/3w0S7U7

This figure shows the life course trajectory of polycystic ovary syndrome from adolescence to postmenopause go.nature.com/3w0S7U7 #PCOS