Thank you to the Medical Alumni Association for hosting a Dean’s Reception in Huntsville tonight. I was glad to attend, say a few words, & gather with colleagues at the @uabheersink Huntsville regional medical campus.

I am so proud of the work we are doing in every corner of AL.

Hello Francisco Rios Yashashwi Pokharel (he/his/him) Sameer Acharya Justin B. Moore, PhD, MS, FACSM Hayden Bosworth This is Guto Montezano from RI-MUHC and I am looking forward to the #HYPHIP chat

Welcome everyone to our chat #HYPHIP Hypertension. Today we have Yashashwi Pokharel (he/his/him) Sameer Acharya Justin B. Moore, PhD, MS, FACSM Hayden Bosworth to talk about their very interesting paper. I am Francisco Rios Francisco Rios from RI-MUHC Montreal (CA), SoMe editor Hypertension and will be the host of the chat

These new data on cardiac outcomes from SSaSS add important new insight into the case for switching from regular salt to potassium-enriched salt in China and around the world@MaoyiT Lijing L. Yan Bruce Neal

ahajournals.org/doi/10.1161/HY…

CENTENNIAL REVIEW: Mineralocorticoid Receptors in Vascular Smooth Muscle: Blood Pressure and Beyond

ahajournals.org/doi/10.1161/HY…

Editorial: Cardiovascular Benefits of Potassium-Enriched Salt Substitution: Promises and Challenges of Secondary Analyses

ahajournals.org/doi/10.1161/HY…

K+-deficient diets, typical of ultra-processed foods, increase blood pressure. Study unveils a mechanism: a new signaling pathway, the K+ switch, and its powerful influence on renal salt rete... Paul A Welling,@[email protected] David Ellison Rick Grimm Rob Fenton Lama Al-Qusairi

ahajournals.org/doi/10.1161/HY…

Lale Ertuglu, MD Guto Montezano Ashley Pitzer Hypertension

Answer to Tanja Dudenbostel, MD, FASH, FAHA #HYPHIP

Wow how time flies by when you are doing something interesting and fun! The end of our chat has arrived, sadly, because I was learning a lot and really enjoying talking to Ashley Pitzer Annet Kirabo D.V.M., M.Sc., Ph.D., F.A.H.A. Lale Ertuglu, MD Thank you so much to you all for being here with us today! #HYPHIP

Annet Kirabo D.V.M., M.Sc., Ph.D., F.A.H.A. Guto Montezano Ashley Pitzer Hypertension In our previous study using CITE-sequence analysis, we found no significant change in the expression of any RAAS-related gene in APCs after salt loading and depletion. Hypertension #HYPHIP Guto Montezano frontiersin.org/journals/physi…

Lale Ertuglu, MD Ashley Pitzer Annet Kirabo D.V.M., M.Sc., Ph.D., F.A.H.A. Hypertension Meena Madhur David G Harrison It would be interesting to know beyond vascular dysfunction, maybe looking at non-invasive measurements in the subjects going on the salt-sensitivity protocol. Not sure if all makes sense though. #HYPHIP Ashley Pitzer Annet Kirabo D.V.M., M.Sc., Ph.D., F.A.H.A. Lale Ertuglu, MD Hypertension

Guto Montezano Ashley Pitzer Lale Ertuglu, MD Hypertension A14 salt-sensitive people have super sensitive and high expression of SGK1. Our data indicates not through the MR. It’s the GR. Aldo does not correlate with salt-sensitive hypertension #HYPHIP Hypertension

Q14 Ashley Pitzer Annet Kirabo D.V.M., M.Sc., Ph.D., F.A.H.A. Lale Ertuglu, MD In your data, you didn't see a role for aldosterone. Do you know if in isolevuglandin-activated APCs, MR activation is increased? And What about cortisol? #HYPHIP Hypertension

Tanja Dudenbostel, MD, FASH, FAHA Guto Montezano Hypertension Ashley Pitzer More in women even in pre-menopause but amplified by menopause

Tanja Dudenbostel, MD, FASH, FAHA Guto Montezano Hypertension Ashley Pitzer We are not yet powered to answer this for immune mechanisms - it is ongoing but all large clinical trials that have rigorously phenotyped salt-sensitivity find it mainly in women

Tanja Dudenbostel, MD, FASH, FAHA Guto Montezano Hypertension Annet Kirabo D.V.M., M.Sc., Ph.D., F.A.H.A. Ashley Pitzer A11 Thank you for this important Q, Tanja Dudenbostel, MD, FASH, FAHA! Previous studies showed that women are affected by SS more. We are studying possible sex differences in immune-cell salt sensitivity in ongoing studies! Hypertension #HYPHIP
pubmed.ncbi.nlm.nih.gov/34569287/

Q 11 Are there any gender differences in salt-sensitivity?
Differences in response to salt loading? #HYPHIP Guto Montezano Hypertension Annet Kirabo D.V.M., M.Sc., Ph.D., F.A.H.A. Ashley Pitzer

~~In OnE HoUr~~
Join Guto Montezano for a #HypHIP Live Chat with @anetkiraboc1, Lale Ertuglu, MD, Ashley Pitzer

Monday April 22, 16:00-17:00 UTC

Salt Series: Eicosanoid-regulated Myeloid ENaC and Isolevuglandin formation in Human Salt-sensitive Hypertension ahajournals.org/doi/10.1161/HY…

~~ToDaY~Mon April 22 11 AM CST ~ Join
Guto Montezano for a #HypHIP Live Author Chat with @anetkiraboc1 Lale Ertuglu, MD Ashley Pitzer
Hypertension #salt 🧂 Series: 🤓Learn more about
Eicosanoid-regulated Myeloid ENaC and Isolevuglandin formation in #APCs in Human 🧂 Salt-sensitive…