This thread is a master class in Medicine 3.0 (preventing and lowering risk) as Peter Attia would describe it.

We could draw similar lines with APOE4 status and Alzheimer’s risk.

Knowledge is power … in people who would act on that info and not be paralyzed with anxiety :)

Great study looking at super agers.

APOE = largest genetic risk variant but other endolysosomal and inflammatory genes play a large role in longevity and lowering dementia risk.

Sweet sweet homeostasis

Very cool work from my Mayo colleagues differentiating the brain networks and clinical symptoms differentiating behavioral clinical syndrome vs dysexecutive clinical syndrome

This was such a massive and impressive effort from Sara Bermudez, spanning cells to mice to humans! A must read for microglia enthusiasts!

The pendulum has swung too far.

Penalizing falls in the hospital has resulted in patients who aren’t allowed to get out of bed.

They get weaker, depressed, constipated, pressure ulcers and ultimately need SNF placement.

Ambulation should be viewed as a key to healing.

Excellent thread on the history about our definition of Alzheimer’s disease from Nicolas Villain

We need personalized medicine sooner than later.

There are many barriers currently to making APOE genotyping common practice in the US:

1) Long term care insurance loophole of genetic protection act
2) cost/insurance coverage
3) genetic counseling of results

Using fire to visualise sound waves

Yay for Hybrid sessions at #AANAM ! Looking forward to session S1 where Dr. Andrew Ho will present our work on neuropathology of MCI at 1 pm Cecilia Tremblay. Also please join my colleagues presenting all things Lewy Body Dementia (C59) with Ryan Townley, Drs Chiu and Shprecher.

Landed in Denver for American Academy of Neurology #AANAM

I present on Early Diagnosis in Lewy Body Disease on 4/14 @ 3:30 in C59

The Dementia Matters podcast overcast.fm/+KjL9FEs9A from Wisconsin ADRC Nathaniel Chin
Living with Lewy Body with Dr. Sara Langer could not have been more timely!

Love this doggy

Fútbol’s finest 🤝 football’s finest.

Leo Messi links up with Patrick Mahomes at Arrowhead Stadium.

Amazing work

AD: is amyloid enough?

A succinct and definitive slide for the second controversy by Dr. David Jones. #AANAM

Landed in Denver for American Academy of Neurology #AANAM

I present on Early Diagnosis in Lewy Body Disease on 4/14 @ 3:30 in C59

The Dementia Matters podcast overcast.fm/+KjL9FEs9A from Wisconsin ADRC Nathaniel Chin
Living with Lewy Body with Dr. Sara Langer could not have been more timely!

Check out the clinico-pathological features of FTDP-17 w/ the MAPT p.K298_H299insQ mutation by Morino and colleagues Movement Disorders Clinical Practice.
Key Points:
- The authors point out that in frontotemporal dementia (FTD) with parkinsonism linked to chromosome 17 (FTDP-17) that the MAPT gene can