Very exciting to see a drug targeting TP53. Hope this succeeds and is the first of many agents.

There is some guidance with basically no snow tomorrow and some with a raging snowstorm

Our job is to try to figure out which ones are the least wrong and come up with an actual forecast 😃

During the #Diagnostic meeting, we will share findings from the HRD Harmonization Project, launch a new #research partnership in Digital and Computational Pathology, and have a policy discussion focused on advancing diagnostic regulation and development.

bit.ly/3t7MYZ3

This is a good one! Matt Shearer

We're recruiting a #postdoc for this ovarian cancer health disparities project! Come join Sikora Lab and Ben Bitler in Colorado.

More on the project here: news.cuanschutz.edu/cancer-center/…

Apply here: cu.taleo.net/careersection/…

What the North Atlantic Ocean went through in 2023 is beyond anything this basin has ever seen in recorded history. Just unbelievable.

Here on the first full day of astronomical winter it is worth pointing out the winter season, Dec-Feb, is the fastest warming season of the year and the northeast is the seeing the most warming of the lower 48. #WeatherWisdom #Climate #WinterSolstice

Prostate cancers with combined BRCA2 and SPOP mutations have greater homologous repair deficiency and increased sensitivity to PARP inhibitors. This is a clinically actionable patient subset! Congrats to our collaborators from 13 centers.
sciencedirect.com/science/articl…

Just published Clinical Cancer Research

Is it a myth🐉that you can’t detect fusions on #ctDNA ?

👇🏾Presenting one of the largest datasets on #LiquidBiopsies & Fusion🖇️detection

53,842 patients
1️⃣4️⃣% had a pathogenic rearrangement detected
Shedding💦matters

OncoAlert

aacrjournals.org/clincancerres/…

Exciting state-of-the art science on use of #AI in diagnosis of #lobular breast cancer. Great presentation by Fresia Pareja #SABCS23

Thank you to the extraordinary team led by Emmanuel Antonarakis who found this critical new piece of the PARP inhibitor puzzle. SPOP mutations are clinically relevant, and we have TWO open clinical trials for folks with refractory SPOP-mutant PC Mayo Clinic Comprehensive Cancer Center.
authors.elsevier.com/a/1iE4o9Cfv-xp…

Dr. Vasan shared the exciting news of the first PIK3CA Patient Advocacy group! Contact us if you would like to help us with this initiative. PIK3CA Path Breakers Abigail Johnston, Esq (she/her) Neil Vasan Lab Marlena Melanie Sisk

A great honour to be allowed to be a small part of the CUPISCO story.

Our #OpenAccess #ResearchPaper on the mutational profile of >450 #patients w #cancer of unknown primary out in ESMO - Eur. Oncology ESMO Open

#PrecisionMedicine OncoAlert 🚨 Linda Mileshkin
esmoopen.com/article/S2059-…

Very interesting work from a huge team (led by Jian Carrot-Zhang from Memorial Sloan Kettering Cancer Center) on associations between %African ancestry and tumor genomics. In particular, they note⬇️KRAS G12C and EGFR L858R, and ⬆️ROS1 fusion with ⬆️african ancestry in lung cancers' sciencedirect.com/science/articl…

Analysis of 260K tumors IDs copy number signatures and a HRD #biomarker predictive of PARPi response ➡️ brnw.ch/21wDiOI Dexter Jin Ethan Sokol #precisionmedicine

Pan-Cancer Analysis of Copy-Number Features Identifies Recurrent Signatures and a Homologous Recombination Deficiency Biomarker to Predict Poly (ADP-Ribose) Polymerase Inhibitor Response ascopubs.org/doi/10.1200/PO…

Thank you to Dr. Steffi Oesterreich and Adrian Lee for the opportunity to speak at this ILC meeting. It was an amazing meeting that brought together patient advocates, physicians, and researchers. I learned a lot and built connections.

Biallelic BRCA Loss and Homologous Recombination Deficiency in Nonbreast/Ovarian Tumors in Germline BRCA1/2 Carriers ascopubs.org/doi/10.1200/PO…

In Clinical Cancer Research #Researchpaper by Kim Reiss Binder (Kim Reiss) & team on reversions in BRCA/PALB2 ✅ #PancreaticCancer #patients treated w PARPi❌

⚠️ Reversions led to💊resistance & poor outcome.

#PrecisionMedicine OncoAlert 🚨 #pancsm 💜
KenOliveLab Joaquin Mateo Anirban Maitra

aacrjournals.org/clincancerres/…