The Asilomar Bioelectronics Symposium is now accepting abstracts! Join us on the California coast this September.

Will Ratcliff I have felt a pretty profound shift. I visit places and actually many trainees feel a strong need to have a translational component to their work. I worry that we have devalued curiosity driven work as a society.

All I see is a transcription factor searching for its target binding site

Some exciting news about my team Nature Communications , we're growing and are looking for a synthetic biologist/metabolic engineer:

nature.com/naturecareers/…

Congratulations Pamela Silver of Harvard Medical School, newly inducted #NASmember ! #NAS161 #biochemistry #biology

Them: so how's it going?
Me: we're really on a roll
The roll 👇
🤣 (sound on)

Now online! Synthetic protein circuits for programmable control of mammalian cell death dlvr.it/T5y2GY

Thrilled to share our new story PNASNews on how an individual TF modulates both local & long-range chromatin movements & structures to start transcription. We integrated nucleus-wide live imaging & functional genomic techniques to answer this question bit.ly/4a41C2Z

How do cells efficiently respond to stress? Transcriptional stress responses are well-known—and in our latest study, we discover that cells use biomolecular condensation to redirect translation from old to new mRNAs 1/n biorxiv.org/content/10.110…

If you put a cancerous (MDA-MB-231) cell on a pattern of two 'basins' connected by a narrow bridge, it hops back and forth like this: why? What is different between it and healthy MCF 10A, which does something slightly different? New preprint from Pedrom Zadeh + me answers this!

#SynBYSS 10AM USA CT
122nd on Apr 18 with Prof Stanley Qi Stanley Qi Lab
& Dr Oskar Staufer Oskar Staufer Leibniz_INM

123rd on Apr 25 with Dr Barbara Gerratana EISMEA European Commission & Prof Katie Galloway Katie Galloway MIT ChemE Dept

Zoom for audience👇
us02web.zoom.us/j/88380504839

🚨Abstract Deadline!!!🚨

PSA: if you have a fourth grader, National Park Service will give him/her a free interagency annual pass. Gets the whole family into any national park. everykidoutdoors.gov/index.htm

It's been great to see the positive response of Rahul Satija & Fabian Theis to our preprint biorxiv.org/content/10.110… on Seurat & Scanpy, and their commitment to work to improve transparency of their tools. One immediate benefit will be better practice of PCA in genomics. 1/🧵

Hey there Stanford University folks, come hear about genetic controllers and cell fate programming. See you on Monday at 4:30 in Shiram 104!
cheme.stanford.edu/events/chemica…

Happy to see this monumental effort by Giovana Breda Veronezi published! cell.com/cell-reports/f…

Memory genes are enriched in CAR T cells that persist and control tumors in patients. But which transcription factors drive beneficial memory programs?

We answer this in our lab’s first paper in nature led by Alex Doan Kat Mueller, PhD Andy Chen. 1/

nature.com/articles/s4158…

Hey there Caltech folks! Want to hear about cell fate programming and genetic controllers? I'll see you tomorrow 4 pm in 106 Spalding

cce.caltech.edu/news-and-event…