CTCF binds dynamically to chromatin during early embryonic development. Wang et al. show that the neuro-protective protein ADPN suppresses CTCF binding, leading to derepression of transposable elements and cell differentiation.

Read more here:
➡️tinyurl.com/gd351189

Research from the Sartorelli lab at NIAMS suggests potential therapeutic interventions to improve muscle regeneration during aging. A new video posted by Genes & Development details the science behind these findings.

📽️ G&D Tapes 📽️

PSAT1 functions as a regulatory link between cellular metabolism, stem cell homeostasis and muscle regeneration. The authors veronica.c and valentina tell us more about their new work in #GenesDev .

Read more here:
➡️tinyurl.com/gd351428

📽️ G&D Tapes📽️

G&D author Carlo Giaccari tells us about how the oocyte-specific protein PADI6 controls DNA methylation essential for early embryogenesis.

Read the full story here:
➡️tinyurl.com/gd351238OA

LTRI’s Dr. Dan Daniel Durocher & co have discovered a new gene (NFATC2IP) that helps keep our genomes intact. This holds potential for therapy as targeting this gene could hinder DNA repair in cancer cells to kill them more effectively via Genes & Development

bit.ly/49ml7mE

How does organelle heterogeneity contribute to cellular diversity and function? Schieweck & Götz answer this question in this comprehensive Review Article:
➡️ tinyurl.com/gd351337

Universität München #OpenAccess

News: Research from the Sartorelli lab at NIAMS suggest potential therapeutic interventions to improve muscle regeneration during aging.

🔒 Published in @genesdev. Read the abstract: pubmed.ncbi.nlm.nih.gov/38453480/

#AKG #MouseModels | NIH NHLBI supported

Novel Rett syndrome variant shines light on new screening strategies for therapies medicalxpress.com/news/2023-10-r… via Medical Xpress

Click here for the full story: ➡️tinyurl.com/genesdev350733

DNA damage remodels the MITF interactome to increase melanoma genomic instability. dlvr.it/T2Ptlg

Investigators showed that MITF, a lineage addition oncogene that coordinates many aspects of #melanocyte and melanoma biology, played a nontranscriptional role in shaping the DNA damage response.

Genes & Development | 🔗 bit.ly/48hDWqS

Immunotherapy plus an investigational cancer drug improves anti-tumor effects medicalxpress.com/news/2023-11-i… via Medical Xpress

Click here for the full story: ➡️tinyurl.com/gd351084

Delighted to share our latest paper led by the great Dali Zong- how inhibition of WRN helicase leads to cell death - and how dual targeting with ATR inhibition may be a useful treatment strategy- in microsatellite unstable cancers: pubmed.ncbi.nlm.nih.gov/37932011/